Infection - Glycopeptides

Question 1

what are glycopeptides?

Answer 1

dalbavancin, teicoplanin, tstevancin + vancomycin

Question 2

what is best route of adminstration for vancomycin

Answer 2

Parental for systemic infections as low absorption with oral routes

Question 3

can you give glycopeptides in pregnancy?

Answer 3

avoid unless benefit outweighs risk

Question 4

how is inital dose dose calculated in vancoymcin?

Answer 4

inital dose is based on body weight then adjusted according to vancomycin concentration

Question 5

what is trough level for vancomycin?

Answer 5

15-20mg/l

Question 6

What can glycopeptides cause?

Answer 6

ototoxicity and nephrotoxicity

Question 7

what are the s/e of glycopeptides?

Answer 7

• red man syndrome
• severe cutaneous adverse steven-johnson syndrome
• blood dyscrasia - agranulocytosis, eosinophilia + neutropenia
• cardiogenic shock on rapid IV inj
• risk of anphylactoid reactions at infusion site avoid rapid infusion and rotate site