Infection Flashcards
what does SIRS stand for?
systemic inflammatory response syndrome
state some symptoms of SIRS?
fever
tachycardia
tachypnoea
leucocytosis
state some pathogens that cause sepsis in neonates ?
group B strep
E coli
listeria monocytogenes
state some pathogens that cause sepsis in children ?
strep pneumonia
meningococci
group A strep
staph aureus
state some symptoms of sepsis ?
fever cold hands prolonged cap refill limb pain vomiting malaise reduced urine output chills
what two things are required for paediatric sepsis?
SIRS and a proven or suspected infection
what is ARDS?
acute respiratory distress syndrome
what is toxic shock syndrome?
warm shock
- vasodilation due to toxins released by strep or staph
what is the presentation of meningitis in children?
Nuchal rigidity, headaches, reduced GCS, seizures, irritability, bulging fontanelle, nappy pain
what investigations should be done for sepsis ?
FBC CRP Coagulation factors blood gases glucose CSF urine culture CT cerebrum (not in acute presentation)
what will the FBC show in sepsis ?
leucocytosis
thrombocytopenia
will the CRP be elevated or reduced during meningitis?
elevated
what will the ABGs show during meningitis ?
metabolic acidosis
will glucose be reduced or increased during meningitis?
reduced
will CSF have increased or reduced protein during meningitis?
elevated
what antibiotics should be used with good CSF penetration for meningitis ?
3rd generation cefalosporins
+ amoxicillin in neonates
with what meningitis infections should close family be treated for as well?
meningococcus B and strep group A
what are some complications of pneumococcal meningitis ?
brain damage
hearing loss
hydrocephalus
what are some complications of meningococcal meningitis ?
amputation and skin scarring
are there vaccinations to reduce the incidence of meningitis ?
yes
- meningoccocal
- pneumococcal
- haemophilus influzena B
what endotoxin does meningococcal disease release?
lipooligosaccharide
- increased levels increases mortality
out of strep and staph what has higher resistance?
staph
what is strep treated with?
penicillins
what is staph treated with?
flucloxacillin