Industrial Toxicology Flashcards

1
Q

what work was published my Ramanzini in 1700

A

De morbis artificum diatribe

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

who identified lead poisoning as the probable cause of devonshire colic in the second half of the 18th C

A

Baker

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

when did Pott draw attention to high rate of scrotal cancer among chimney sweeps

A

2nd half of 18th C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what did the several what did ramazzinis work describe

A

the symptoms of diseases found in the workplace

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what did the 1895 workshop act state

A

industrial diseases must be reported

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

when was the workmens compensation act passed and what did it state

A

1897, those injured should be compensated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

in which year was the first factory inspector appointed

A

1898

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what did the 1911 national health insurance act state

A

covered workers for sickness and disablement benefits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what was the purpose of the 1946 national insurance injuries act

A

provided compensation for loss of ability to wokr

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

when was the health and safety at work act which underpins current legislation passed

A

1974

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

how many tonnes of asbestos are mined each year

A

2million

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what is white asbestos called

A

chrysotile

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

ehat is blue asbestos called

A

crocidolite

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is brown asbestos called

A

amosite

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

which forms of asbestos can be spun

A

chrysolite and crocidolite

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what is amosite used ofr

A

cement/plaster boards

17
Q

what is the structure based on

18
Q

what is sandwiched between layers of SiO2 in asbestos

A

layers of metal oxides

19
Q

when was concern raised over high incidences of lung disease in factories and who by

A

lucy deane, late 1890s

20
Q

why was no link found between factory work and lung disease in late 1890s by government commision

A

high incidence of Tb in working class

21
Q

when was lung disease as a result of exposure to asbestos first recognised

22
Q

when was the asbestos regulations act introduced

23
Q

why were the 1968/9 asbestos regulations act inadequate

A

set the acceptabl level of exposure too high

24
Q

when was the masacre at hebden bridge

25
what was the result of the masacre
advisory commitee apointed to review 1968 act
26
when was the act passed to ban the use of asbestos in the EU from 2006
2003
27
whatare the symptoms related to asbestos poisoning
inflammation and progressive fibrosis of the lung, lung cancer and mesothelioma
28
what is the safe limit
there isnt one
29
why is asbestos so biopersistent
poorly soluble andto long to be phagocytosed or cleared by cilia
30
how do numbers of chrisotile fibres increase over time
they split longitudnally
31
what often occurs if phagocytosis does occur and what is the result
phacocytic vesicles rupture, releasing proteolytic enzymes and fibres into the lung tissue causing an inflammatory response
32
what allows asbestos fibres to form reactove oxygen species
iron (II) which catalyses hydroxyl radical formation
33
what is the result of reactive oxygen species formation
dna damage, lipid peroxidation
34
how many countries have banned its use
52
35
how many predicted deaths from mesothelioma will there be by 2050
90,000
36
how many people are estimated to die of asbestos related diseases each year
100000
37
what effects do fibroblasts have on collagen
increase type one and reduce type three making it less flexible