History of Toxicology Flashcards

1
Q

in what year was the “Treatise on Poisons” by mathieu Orfila published

A

1817

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2
Q

who published the first treatise on industial hygiene in 1831

A

Charles Turner Thackrah

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3
Q

in which decade was morphine first isolated from opium and quinine isolated from cinchana bark

A

1830’s

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4
Q

which two scientists developed the first reliable tests for arsenic around 1836/1842

A

marsh and reinsch

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5
Q

what did yamagiwa and ichikawa prove in 1915

A

coal tar leads to tumors- first demonstration of chemical carcinogens

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6
Q

what toxin did the team lead by Gerhard Schroder develop

A

organophosphate insectisides and nerve gases such as sarin and tabun

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7
Q

what is the anti-lewisite antidote developed by Sir Rudolf Peters in the 1940’s used in the treatment of

A

mercury lead gold and arsenic

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8
Q

in what year did the london smog occur

A

1952

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9
Q

in which year was the clean air act passed

A

1956

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10
Q

what did the US delancy clause (1958) state

A

any substance found to be carcinogenic may not be added to food in the US

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11
Q

what year was the thalidomide disaster in

A

1961

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12
Q

in which decade was the minimata bay disaster

A

1960s

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13
Q

which century was the ebers papyrus made in

A

1500 BC

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14
Q

in what war were poison arrows supposedly used and what century was this

A

trojan war 1200BC

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15
Q

when was socrates murdered

A

399BC

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16
Q

what did mithridates VI of Pontus discover in 100BC

A

a complex mixture of aantidotes known as mithridatium

17
Q

what was the name of the laws passed which stated that poisoning and sale, purchase and possesion of poisonous substances was illegal, and who were they passed by and when

A

lex cornelia passed by Sulla in 32BC

18
Q

when did Nicander of Colophan write the oldest book on the subject to survive from antiquity

A

1150AD

19
Q

when did Pietro d’Abano produce “liberde venenis”

A

1402

20
Q

who came up with the central dogma of toxicology in 1500

A

Paracelsus

21
Q

during which period was poisoning by the Borgia and Medici families for power money and sex a common occurence

A

renaissance

22
Q

which scientist performed groundbreaking experiments on snake venoms and plant poisons in 1770

A

Felice Fontana

23
Q

in which year did Sir Percival Potts report a high incidence of scrotal cancer in chimney sweeps

A

1775

24
Q

who produced a work on the health of workers in 1800

A

Bernadino Ramazzini