Inate and humoral immunity Flashcards
megakaryocytes (platelets) are not part of immune system, but participate in ___________
inflammation
what cells are NOT typically found in tissues
macrophages
dendritic cells
mast cells
Cytotoxic T cell
CD8- MHC1
Helper T
CD4- MHC2
cells in inmate humoral (extracellular immunity)
myeloid cells - neutrophils, macrophages, mast cells, eosinophils
non host epitopes- protein that is not part of our immune system, ex- on bacteria
changes over time based on what the body encounters
B-cells, antibodies, T-helper, APC’s
produce antibodies that are very specific- takes time
Adaptive humoral immunity
NK cells, MHC existence
innate- cell mediated immunity
cytotoxic t cells- if it sees an abnormal cell it kills it
cell mediated adaptive immunity
what cells are all over the body and wait for something to happen, they are responsible for the innate response
macrophages- they also recognize the possibility of bacteria
engulfs bacteria and releases CYTOKYNES
macrophages
Messenger among immune cells- innate inflammation
cytokines
cytokines trigger ________ that allow neutrophils that have been circulating blood to come and engulf bacteria
chemokynes
INFLAMMATION:
Cell injury or pathogenic invasion causes the activation of ________________ , __________ , __________ which activates the 1)____________, 2)____________, and 3)______________ responses
plasma systems, release of cellular products, mast cell degranulation
- compliment
- clotting
- Kinin
INFLAMMATION:
redness and heat
vasodilation
INFLAMMATION:
cellular infiltration
pus
INFLAMMATION:
thrombosis
clots
INFLAMMATION:
stimulation of nerve endings
pain
INFLAMMATION:
histamine release and chemotactic factors attract neutrophils + eosinophils
mast cell degranulation
INFLAMMATION:
prostaglandins, prostacyclins, leukotrienes and thromboxjnes
have inflammatory in immune functions
4 families of ecosinoids
removal of arachidonic acid + EPA from plasma membrane
Phosposlipase A2 - a biologic mediator synthesized from mast cells
converta arachidonic acid to prostaglandins, prostacyclins and thromboxane
Cyclooxygenase a biologic mediator synthesized from mast cells
blocked by steroids
phospholipase A2
blocked by COX-1 inhibitors - ASA, ibuprofen and selective cox II inhibitors like vioxx and celebrex
cyclooxygenase
what is the timeline of leucocyte infiltrates in inflammatory reactions such as ischemic necrosis/ infarction?
- immediate edema
- day one- neutrophils peak neurtrophilic infiltrates and congested blood vessels
- monocytes peak later, day 2, come into tissue and cover to macrophages to start repair
- repair process- repair damaged tissue with scar tissue
Scar tissue in cardiac ischemia is ____________ and results in ____________.
non contractile
loss of function
Initial steps of phagocytosis include adherence of neutrophils to the vessel wall (__________) retraction of ________________(vascular permeability), and movement of neutrophils through the vascular spaces (___________), the cells move up the gradient by ____________.
pavementing, endothelial cells, diapedesis,chemotactic factors
adherence of neutrophils is optimized by
antibody and opsonins
opsonins bid to
epitopes
engulfment into
phagocytotic vacuole or phagocyte
after a bacteria is engulfed the phagosomes are fused by…
lysosomes- which will produce reactive oxygen species hydrogen peroxide and superoxide to kill the microorganism
seconds to minutes- swelling vessel leakage, ENDOTHELIAL ADHESION
INTEGRINS & SELECTINS
Initial cytokyne response
stops rolling neutrophils, first line of defense
initial cytokyne response
Histamine, kinins, leukotriens, prostaglandin, IL-1 snf TNF
initial cytokyne response
neutrophils that are stopped by damage, diapedesis, chemotaxis, send signals to more cells
cytokine response causing recruitment of cells
activation of leukocytes, lymphocyte growth, antibody synthesis
cytokyne response causing removal of debris
induce fibroblast growth and collagen production
cytokyne respons to promote regenteration and repair
granulocyte colony stimulating factor
cytokine response causing recruitment of cells
platelet derived growth factor (PDGF)
cytokyne respons to promote regenteration and repair
Fibroblast growth factor (FDG)
cytokyne respons to promote regenteration and repair
Tumor Necrosis factor TNF
is active in all four stages of cytokine involvement with inflammation
there results of chronic inflammation
- angiogenesis
- mononuclear cell infiltrate
- SCAR formation
loss of function
fibrosis
mediators, neutrophil recruitment, swelling
acute inflamation
clearance of injurious stimuli, clearance of mediators and acute inflammation cells, replacement of injured cells, normal function
resolution
when b and t cells find an antigen
they are activated- clonal selection leads to clonal proliferation and expansion.
somatic hypermutation
activated b cells
produce free floating antibodies
b cells that become plasma cells
do NOT undergo somatic hypermutation
T-cells
____________ help ___________ to mature
helper T cells
naive b cells
cytotoxic T cell
adaptive immunity
NK cells
Innate immunity
bone marrow, thymus
primary lymphoid tissue
lymph nodes
2ndarey lymphoid tissue - none in brain, kidneys or bones
lymph from brain drains to
cervical lymph nodes
Mucosal/ gut associate lymph tissues
MALT/GALT
pyers patches ilium of small intestine
tonsils and adenoids
BALT
in lungs, bronchial associated lymph tissue
antigenic determinants that B or T cell bind to
Epitopes - the more epitopes the more the chance of binding
antigen binding domain
variable region
determines antibody class
constant region
antibody most common in blood
IgG
only antibody that can cross placenta
IgG
all antibodies start as these
IgM or IgD
pentamer
IgM
monomer
IgD, IgE, IgG
antibody of allergies found tin tissues and bound to mast cells
IgE
causes allergic Rhinitis
IgE