Chronic disorder of neurologic function Flashcards
characterized by excessive cortical electrical discharges and spontaneous positive potentials r/t Na+
Seizure disorder
neurons are hyperactive and hypersensitive to their environment
seizure disorder pathogenesis
decreased distance between membrane and threshold potential
neurons hypersensitive
Anticonvulsants target
- Positive ions, Na+ and Ca++ (depolarization of the cell)
2. Enhance GABA- inhibitory (hyper polarize cell- Cl-)
PROGRESSIVE deterioration and CONTINUING decline of memory and cognitive changes
Dementia
two types of dementia
Alzheimers and Vascular
degeneration of CORTICAL neurons in temporal and frontal lobes
dementia
brain atrophy around TEMPORAL
amyloid plaques
neurofibulary tangles
Alzheimers
Characterized by a LOSS of function
Alzheimers disease
mild cognitive impairment
NOT Alzheimers
plaques and tangles
proteinopathies
extracellular space
plaques
intracellular space
tanagles
B- amyloid deposits
Plaques
Tau Protein
Tangles
dense central AB core with inflammatory cells and DYSTROPHIC neurites in periphery
plaques
high potential for aggregation and accumulation
plaques
paired helical filament configuration
tangles
disassociates from microtubule and begins to fold
tangles
AB peptide gets clever into
AB42
B-amaeyloid is a byproduct that exists EXTRACELLULARLY and gets cleared in 3 ways normally
- Uptake by another neuron
- Macrophages
- enzymes
INCREASED in alzheimers
CSF Tou
normally stays in neuron membrane, if it has increased in CSF it has LEAKED out of the neuron and their is an accumulation.
DECREASED in alzheimers
- AB42 normally in CSF, if it is decreased it has accumulated somewhere else (extracellular space)
- FDG PET - glucose metabolism ahs decreased indicating decreased neuronal function (neurodegerative disease)
most common byproduct of alzheimers
AB42
risk factor for alzheimerw
E4 allele of APOE has a higher affinity for B-Amyloid
INCREASES metabolism, INCREASES aggregation and DECREASES clearance of AB peptide
E4 allele of APOE
how do we increase or cognitive reserve
exercise your brain and start with a higher baseline
syndrome with evidence of CLINICAL STROKE or VASCULAR BRAIN INJURY
dementia; vascular cognitive impairment
cognitive impairment r/t cerebrovascular injuries
vascular dementia
communication with WHITE MATTER degrades
vascular dementia