in class corticosteroids Flashcards

1
Q

ENDOCRINE SYSTEM FUNCTION

works off of

A

Chemical messengers tell the glands when to release hormones

Works off a feedback loop

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2
Q

adrenal cortex hormones and effects

A

aldosterone-increases blood na level

cortisol-increases blood sugar level

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3
Q

adrenal medulla hormone and effect

A

epinephrin and norepineherin

stimulates fight or flight

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4
Q

pancreas hormone and effect

A

insulin Reduces blood glucose level

Glucagon Increases blood glucose level

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5
Q

thyroid hormone and effect

A

Thyroxine (T4) & Triiodothyronine (T3) Stimulates basal metabolic rate

Calcitonin Reduces blood Ca+ level

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6
Q

hormone pharmacotherapy is given when

A

When the body can’t produce enough

To shrink hormone-sensitive tumors

Produce an exaggerated response

Block the action of hormones

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7
Q

who runs endocrine system

A

hypothalamus

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8
Q

ADRENOCORTICOTROPIC
HORMONE (ACTH
ant pituitary gland

A

Targets the adrenal gland to release cortisol

Regulates BP, sugar, immune system & stress response

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9
Q

THYROID-STIMULATING (TSH)
ant pituitary gland

A

Targets the thyroid

Stimulates the thyroid to release T3/T4

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10
Q

PROLACTIN ant pituitary gland

A

Targets the mammary gland

Promotes milk production

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11
Q

FOLLICLE-STIMULATING
HORMONE (FSH)
ant pituitary gland

A

Targets the ovaries

Promotes ovulation

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12
Q

LEUTENIZING HORMONE (LH)
ant pituitary gland

A

Targets the ovaries (women)
Targets the testes (men)

Promotes ovulation
Produces testosteron

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13
Q

GROWTH HORMONE
ant pituitary gland

A

Targets nearly every cell in the body

Stimulates growth & metabolism

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14
Q

oxytocin
post pit gland

A

Targets the uterine smooth muscle

Promotes uterine contraction in labor

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15
Q

ANTI-DIURETIC
HORMONE (ADH
post pit gland

A

Acts on collecting ducts of the kidneys

Increases water reabsorption (deficiency can cause DI)

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16
Q

adrenal cortex
secretes
use
regulates

A

secretes steroids

LONG-TERM stress adaptation

Regulates stress response, blood pressure, blood volume, nutrient uptake & storage, fluid & electrolyte balance, inflammation

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17
Q

adrenal medulla
secretes
mediatedby

A

Secretes epinephrine & norepinephrine

SHORT-TERM stress adaptation

Mediated by the Sympathetic Nervous System (SNS)

18
Q

pancreas

A

Secretes Glucagon using glycogenolysis & gluconeogenesis, raising blood glucose levels

Secretes Insulin to promote the uptake of glucose into skeletal and adipose body cells & liver to produce glycogen, lowering blood glucose levels

19
Q

thyroid
secretes
required
sensitivity
regultes

A

Secretes calcitonin, decreasing calcium levels in blood

Required for protein synthesis and fetal/childhood development and tissue growth

Increases sensitivity to Epi/NorEpi, affecting heart

Regulates basal metabolic rate

20
Q

Type I Diabetes

A

Autoimmune disease impacting beta cells of the pancreas

Beta cells DO NOT produce insulin

Irreversible but treatable

Treat with synthetic insulin

Cannot use oral medications

21
Q

Type II Diabetes

A

Acquired

Body cells become resistant to the effects of insulin

Results from poor diet and inactivity

Reversable & preventable with weight loss, physical activity, and a healthy diet

Treat with oral medications first

May need insulin if uncontrolled or hositalized

22
Q

Hypoglycemia
s/s
risks
treatment

A

s/s: Hunger, shakiness, fatigue, sweaty, clammy/pale skin, headache & dizziness

Blood glucose < 70 or Severe <40

Risks: Use of Beta-Blockers & exercise

Treatment: 15/15 rule, Dextrose 50% IV, or Glucagon pen

23
Q

hyperglycemia

s/s
what puts you at risk
complications
treatments

A

s/s: Polyuria, polydipsia, polyphagia, weight loss, fatigue, non-healing wounds, blurred vision

Blood glucose > 130 (2 separate occasions)

Risks: Stress, infection, steroid use

Complications: Heart disease, stroke, amputations, neuropathy, nephropathy, retinopathy

Treatment: Insulin & exercise/activity

24
Q

DKA

s/s
what puts you at risk
complicaitions
treatment

A

s/s: Blurred vision, fruity breath, Kussmaul’s respirations, flushed/dry/warm skin

Risks: Glucose > 300, stress, infection, steroid use, poorly managed diabetes

Complications: Coma and death

Treatment: Hospitalization (fluids/insulin IV)

25
Hypothyroidism cause s/s treatment
Cause: Inflammation of thyroid gland S/S: Low Metabolic Rate, weight gain, cold extremities, constipation, reduced libido, menstrual irregularities, reduced mental activity Treatment: Levothyroxine.... FOREVER
26
Hyperthyroidism cause s/s treatment
Cause: Pituitary or thyroid tumor, Graves Disease, Enlarged thyroid (goiter) S/S: Increased Metabolic Rate, weight loss, excessive body heat, sweating, diarrhea, tremors/nervousness, increased heart rate/palpitations, exophthalmos Treatment: Radioactive Iodine (RAI), Thyroid Surgery, Propylthiouracil (PTU) all followed by Levothyroxine... FOREVER
27
Corticosteroids useage causes stop
Available oral, IV, topical Used for a variety of reasons (suppress inflammation) Comes with great effects but great risks Can cause adrenal suppression, hyperglycemia, cardiovascular disease (weight gain), bone pain, bruising, poor wound healing and immunosuppression Never stop abruptly (HPA suppression)
28
Insulin Pen
individually used Ready for administration Can be self-administered Increases safety with insulin administration Less prep time required Reduces medicine waste Not commonly used due to cost
29
Insulin Pump
Provides precise dose of insulin based on blood glucose Can pair with continuous glucose monitor Patient must count carbohydrates Patient may need to readjust dosing with increased activity Easier to handle sick days
30
Rapid-Acting Insulin (Lispro/aspart given appearance dosage opd
Given 15 minutes before meals or with meals Appears clear and colorless Dose depends on carbohydrate intake, glucose levels or anticipated activities May be given as a basal rate and/or sliding scale Onset 15-30 minutes Peak 1-3 hours Duration 3-5 hours
31
Short-Acting Insulin (Regular
Administered with meals Individualized based on carb intake, premeal glucose levels, and anticipated activity Should be given 30 minutes of eating to avoid hypoglycemia Can be given IV – THE ONLY ONE!!! Onset 30 min Peak 3 hours Duration 8 hours
32
Intermediate-Acting Insulin
Given once or twice daily Appears white and cloudy Gently roll or invert to resuspend insulin Can be mixed with short or rapid-acting insulin Draw up cloudy-clear-clear-cloudy Onset 1-2 hours Peak 6 hours Duration Up to 24 hours
33
Long-Acting Insulin (Glargine)
Usually given once daily Appears clear and colorless CANNOT be mixed with other insulins Given subcutaneous Onset 3-4 hours Peak None Duration > 24 hours
34
Glucagon Pen
Increases blood glucose concentration rapidly Treatment for severe hypoglycemia Available SubQ, IM, IV, or PO Given if patient is unable to swallow Peak: 13-20 minutes after injection
35
Sulfonylurea (Glipizide) stimulates causes peak s/e
Stimulates the release of insulin and increases sensitivity at receptor cells Taken at the same time each day Can cause disulfiram-like reaction – No alcohol Peak: 1-3 hours after 1st dose S/E: Weight gain and hypoglycemia
36
Biguanide (Metformin) contraidicated/stop casues eat s/e
Contraindicated in patient’s with kidney disease Stop immediately with s/s of lactic acidosis Hold/stop if having a radiologic study using iodine Can cause metallic taste in the mouth Does NOT produce hypoglycemia Take at the same time each day Eat a healthy diet and incorporate exercise S/E: N/V, diarrhea, weakness, flatulence, indigestion, abdominal discomfort, headache
37
DPP-IV Inhibitor (Sitagliptin) increases take stop s/e
Increases insulin production and decreases hepatic glucose overproduction Take at the same time each day (with or without food) Stop with hypersensitivity S/E: Hypoglycemia
38
Levothyroxine what is take w/@ monitor s/e
Synthetic T4 that is taken FOREVER Take with full glass of water and 30 min before breakfast or 4 hours before/after drugs that interfere with absorption (antacids, iron, calcium) Take at the same time each day Monitor serum thyroid closelyand weight S/E: Overtreatment = hyperthyroidism, drug-to-drug interactions
39
Propylthiouracil (PTU) used given notify s/e
Used to treat hyperthyroidism in preparation for thyroidectomy or RAI Given every 8 hours Notify PCP if you become pregnant S/E: Hypothyroidism, liver failure, agranulocytosis, vasculitis, and fetal harm
40
Radioactive Iodine (RAI)
Given in pill or liquid form to destroy the thyroid gland and thyroid cancer cells Harmful to pregnant women and small children Patients must sleep in separate beds Flush toilet 2-3 times daily Cover cough/sneeze with Kleenex S/E: Hypothyroidism (will need Levothyroxine after treatment)