in class corticosteroids Flashcards
ENDOCRINE SYSTEM FUNCTION
works off of
Chemical messengers tell the glands when to release hormones
Works off a feedback loop
adrenal cortex hormones and effects
aldosterone-increases blood na level
cortisol-increases blood sugar level
adrenal medulla hormone and effect
epinephrin and norepineherin
stimulates fight or flight
pancreas hormone and effect
insulin Reduces blood glucose level
Glucagon Increases blood glucose level
thyroid hormone and effect
Thyroxine (T4) & Triiodothyronine (T3) Stimulates basal metabolic rate
Calcitonin Reduces blood Ca+ level
hormone pharmacotherapy is given when
When the body can’t produce enough
To shrink hormone-sensitive tumors
Produce an exaggerated response
Block the action of hormones
who runs endocrine system
hypothalamus
ADRENOCORTICOTROPIC
HORMONE (ACTH
ant pituitary gland
Targets the adrenal gland to release cortisol
Regulates BP, sugar, immune system & stress response
THYROID-STIMULATING (TSH)
ant pituitary gland
Targets the thyroid
Stimulates the thyroid to release T3/T4
PROLACTIN ant pituitary gland
Targets the mammary gland
Promotes milk production
FOLLICLE-STIMULATING
HORMONE (FSH)
ant pituitary gland
Targets the ovaries
Promotes ovulation
LEUTENIZING HORMONE (LH)
ant pituitary gland
Targets the ovaries (women)
Targets the testes (men)
Promotes ovulation
Produces testosteron
GROWTH HORMONE
ant pituitary gland
Targets nearly every cell in the body
Stimulates growth & metabolism
oxytocin
post pit gland
Targets the uterine smooth muscle
Promotes uterine contraction in labor
ANTI-DIURETIC
HORMONE (ADH
post pit gland
Acts on collecting ducts of the kidneys
Increases water reabsorption (deficiency can cause DI)
adrenal cortex
secretes
use
regulates
secretes steroids
LONG-TERM stress adaptation
Regulates stress response, blood pressure, blood volume, nutrient uptake & storage, fluid & electrolyte balance, inflammation
adrenal medulla
secretes
mediatedby
Secretes epinephrine & norepinephrine
SHORT-TERM stress adaptation
Mediated by the Sympathetic Nervous System (SNS)
pancreas
Secretes Glucagon using glycogenolysis & gluconeogenesis, raising blood glucose levels
Secretes Insulin to promote the uptake of glucose into skeletal and adipose body cells & liver to produce glycogen, lowering blood glucose levels
thyroid
secretes
required
sensitivity
regultes
Secretes calcitonin, decreasing calcium levels in blood
Required for protein synthesis and fetal/childhood development and tissue growth
Increases sensitivity to Epi/NorEpi, affecting heart
Regulates basal metabolic rate
Type I Diabetes
Autoimmune disease impacting beta cells of the pancreas
Beta cells DO NOT produce insulin
Irreversible but treatable
Treat with synthetic insulin
Cannot use oral medications
Type II Diabetes
Acquired
Body cells become resistant to the effects of insulin
Results from poor diet and inactivity
Reversable & preventable with weight loss, physical activity, and a healthy diet
Treat with oral medications first
May need insulin if uncontrolled or hositalized
Hypoglycemia
s/s
risks
treatment
s/s: Hunger, shakiness, fatigue, sweaty, clammy/pale skin, headache & dizziness
Blood glucose < 70 or Severe <40
Risks: Use of Beta-Blockers & exercise
Treatment: 15/15 rule, Dextrose 50% IV, or Glucagon pen
hyperglycemia
s/s
what puts you at risk
complications
treatments
s/s: Polyuria, polydipsia, polyphagia, weight loss, fatigue, non-healing wounds, blurred vision
Blood glucose > 130 (2 separate occasions)
Risks: Stress, infection, steroid use
Complications: Heart disease, stroke, amputations, neuropathy, nephropathy, retinopathy
Treatment: Insulin & exercise/activity
DKA
s/s
what puts you at risk
complicaitions
treatment
s/s: Blurred vision, fruity breath, Kussmaul’s respirations, flushed/dry/warm skin
Risks: Glucose > 300, stress, infection, steroid use, poorly managed diabetes
Complications: Coma and death
Treatment: Hospitalization (fluids/insulin IV)