exam 4 presentaion first Flashcards
what do corticosteroids do
Glucocorticoids cause profound and varied metabolic effects and modify the body’s immune responses
Corticosteroids examples
Prednisone (PO) / methylprednisolone (IV) / hydrocortisone cream (topical)
what are corticosteroids used for
Used as replacement therapy in adrenal insufficiency (Addison’s)
various dermatologic, ophthalmologic, rheumatologic, pulmonary, hematologic, and gastrointestinal disorders
specific diseases corticoseroids
Endocrine disorders such as adrenocortical insufficiency
Rheumatic disorders such as rheumatoid arthritis
Collagen diseases such as systemic lupus erythematosus
Dermatologic diseases such as severe psoriasis
Allergic states such as contact dermatitis or drug hypersensitivity reactions
Ophthalmic diseases such as optic neuritis
Respiratory diseases such as asthma or COPD
Neoplastic diseases such as leukemia
good bad ugly corticosteroids
The Good:
Reduce inflammatory responses (suppressing
the immune system)
The Bad:
If stopped abruptly it cancause impaired stress response (HPA suppression)
The Ugly:Comes with great risks, adverse effects,and side effects
Corticosteroids Adverse & Side Effects
Osteoporosis / Fractures
Adrenal Suppression
-Development of Cushing’s syndrome
–Patients with adrenal disorders may develop altered corticosteroid secretion
Hyperglycemia & Diabetes
Cardiovascular Disease & Dyslipidemia
-Weight gain
Dermatological Events
-Thin, Fragile skin that bruises easily
- Poor wound healing
GI Events
-Peptic Ulcers
Emotional Disturbances
-Varying from euphoria, insomnia, mood swings, personality changes to severe
depression
Immunosuppression
-Increase the risk of Infection
- May mask some signs of infection, and new infections may appear during their
use.
risk factors corticosteroids
Diabetes
Dyslipidemia
Cerebrovascular Disease (CVA)
GI Disorders
Affective Disorders
Osteoporosis
Corticosteroids Teaching:
Never stop abruptly!!!–taper dose down gradually
Report adverse/side effects
Unusual swelling
Weight gain
Fatigue
Bone pain
Bruising
Non-healing sores
Visual/Behavioral disturbances
Report new signs of infection
Can cause immunosuppression making it difficult to detect signs of infection
what to monitor for corticosteroids and what diet
Monitor blood glucose levels
Can cause hyperglycemia
Eat diet high in protein, calcium, and potassium
ANTIDIABETICS
regulates what
Regulation of blood glucose levels by insulin and glucagon
what is glucose
Glucose is the preferred fuel for all body cells. The body derives glucose from the breakdown of
the carbohydrate-containing foods and drinks we consume.
where is glucose stored
Glucose not immediately taken up by cells for fuel can be stored by the liver and muscles as glycogen or converted to triglycerides and stored in the adipose tissue. Hormones regulate both the storage and the utilization of glucose as required
what receptors for glucose
Receptors located in the pancreas sense blood glucose levels, and subsequently, the pancreatic cells secrete glucagon or insulin to maintain normal levels.
INSULIN does what
Insulin facilitates the uptake of glucose into skeletal and adipose body cells. The presence of food in the intestine triggers the release of gastrointestinal tract hormones
insulin production
triggers insulin production and secretion by the beta cells of the pancreas. Once nutrient absorption occurs, the resulting surge in blood glucose levels further stimulates insulin secretion
insulin promotes and secreteion
insulin promotes triglyceride and protein synthesis.
The secretion of insulin is regulated through a negative feedback mechanism.
As blood glucose levels decrease, further insulin release is inhibited.
what cant happen wihtout insulin
Without insulin, glucose cannot enter cells
GLUCAGON why released
Receptors in the pancreas can sense the decline in blood glucose levels, such as during periods of fasting or during prolonged labor or exercise. In response, the alpha cells of the pancreas secrete the hormone glucagon
affects of glucagon
what does it stimulate
it stimulates glycogenolysis– liver convert stores of glycogen back into glucose. glucose is then released into the circulation for use by body cells.
It stimulates gluconeogenesis- liver take up amino acids from blood and convert into glucose.
It stimulates lipolysis, the breakdown of stored triglycerides into free fatty acids and glycerol.
g;ucose level a1c level
Glucose level
(Normal Range):
80-130 mg/dL
Target A1c level:
7%
type 1 diabetes
Autoimmune disease impacting the beta cells of the pancreas
Beta cells do not produce insulin
Administer synthetic insulin instead
Irreversible but treatable
Use insulin to treat
type 2 diabetes
Acquired
–Result of poor diet and inactivity
Body cells become resistant to the effects of insulin
Reversable/preventable with weight loss, physical activity, healthy diet
Treated with oral medications (first) after diet and exercise are not successful
May require insulin if uncontrolled and during hospitalizations d/t stress
95% of all diabetes is Type II
nursing process diabetes assess implent eval
Assessment:
Continuous monitoring for hypo- and hyperglycemia. This is low and high blood glucose levels.
Assess patients with presence of stress or infection d/t increased blood glucose levels
Implementation:
Follow agency policies/guidelines for safe insulin administration
Administer insulin at timed intervals in accordance with meal-times to prevent hypoglycemia
Understand onset and peak of medication
Response/intervene quickly with the presence of hypoglycemia (per protocol)
Report event to provider immediately
Report to next RN in shift report
Evaluation:
Assess hemoglobin A1c or glycohemoglobin every 3, 6, 9, or 12 months depending on provider recommendation
Target A1c is 7% (but vary according to age and health)
hypolgycemia
protocols
monitor
caution w/
doses
Requires IMMEDIATE treatment by the nurse
Follow healthcare agency protocols ((( 15g of rapid digested carbohydrates (if tolerated) —-4 oz of fruit juice—– If NPO, give dextrose 50% IV or glucagon IM)))
MONITOR PATIENT CLOSELY!!!! and Hypokalemia
Caution w/ patients on Beta-Blockers as they can develop low blood sugars without symptoms
Doses may need adjustment w/ exercise
