Important for Exam II

Question 1

What 2 things do Oseltamivir (Tamiflu) and Peramivir (Rapivab) have in common? (besides the fact that they are both NA inhibitors for flu)

Answer 1

1) Require renal dosing
2) GI & neuropsychiatric side effects

Question 2

Which 2 NA inhibitors (for flu) are 5 day treatments?

Answer 2

Oseltamivir (Tamiflu) & Zanamivir (Relenza)

Question 3

What is the preferred Tx for influenza in pregnancy?

Answer 3

Oseltamivir (Tamiflu)

Question 4

Which NA inhibitor (for flu) is given via IV for 1 day?

Answer 4

Peramivir (Rapivab)

Question 5

1) Which NA inhibitor (for flu) is given via capsule or solution?
2) Which is via diskhaler?

Answer 5

1) Oseltamivir (Tamiflu)
2) Zanamivir (Relenza)

Question 6

Define each type of pneumonia:
1) CAP (community)
2) HAP (hospital)
3) VAP (ventilator)

Answer 6

1) Pneumonia developing outside the hospital or <48 hrs after admission
2) Pneumonia developing >48 hrs after admission
3) Pneumonia developing >48 hrs after endotracheal intubation

Question 7

What is CURB-65?

“will be tested on a lot”

Answer 7

Confusion
Uremia (BUN > 20 mg/dL [7.1 mmol/L])
Respiratory rate ≥30 breaths/min
Blood pressure (systolic <90 mm Hg, diastolic ≤60 mm Hg)
Age ≥65 years

Question 8

True or false: Most treatments for COPD have not been shown to improve survival or to slow the progressive decline in lung function

Answer 8

True

Question 9

Nicotine cessation products:
1) What is the MOA of varenicline?
2) What are the other options?
3) What is allowed for Tx in the UK but not US?

Answer 9

1) Partial agonist on nicotinic receptors
2) Tricyclic antidepressants, behavioral therapy and hypnosis
3) E-cigarettes; due to missing long-term safety data (UK is exception)

Question 10

Nicotine cessation products:
1) Who should you avoid bupropion for?
2) Who is NRT contraindicated for?
3) What does varenicline do?

Answer 10

1) For patients with PMH of seizures or eating disorders
2) With recent (w/in 2 weeks) stroke or MI
3) Relieves physical withdrawal symptoms and reduces the rewarding properties of nicotine

Question 11

True or false: ICS monotherapy for patients with COPD is not recommended

Answer 11

True

Question 13

True or false: ICS/LABA dual Tx is not recommended for COPD pts, but is for asthma pts

Answer 13

True

Question 14

What is not to be used as monotherapy for long term control of asthma bc of an increased risk of death?

Answer 14

Long-acting (LABA) – dosed twice daily:
Salmeterol (Serevent)
Formoterol (Foradil, Performist)

Question 15

Mometasone furoate DPI (Asmanex): How do you dose this for chronic asthma?

Answer 15

Low: 110-220
Med: 220-440
High: 440