Exam 3 drug groups

Question 1

What are 2 Carbonic Anhydrase Inhibitors [epilepsy]?

Answer 1

Topiramate and Zonisamide

Question 2

What are 4 GABA Modulators for epilepsy?

Answer 2

Cool People Pet Cats
1) Clonazepam
2) Phenobarbital
3) Primidone
4) Clobazam

Question 3

7 Na+ channel inhibitors for epilepsy?

Answer 3

Come On People, Let’s Lick Every Road [for salt]
1) Carbamazepine
2) Oxcarbazepine
3) Phenytoin
4) Lamotrigine
5) Lacosimide
6) Eslicarbazepine
7) Rufinamide

Question 4

3 Ca+ inhibitors for epilepsy?

Answer 4

Everyone Gets Pregnant [and gets their calcium stolen by their fetus]
1) Ethosuximide
2) Gabapentin
3) Pregabalin

Question 5

What are the 3 misc. epilepsy drugs?

Answer 5

1) Cannabidiol
2) Felbamate
3) Perampanel

Question 6

What are 2 GABA transaminase inhibitors for epilepsy?

Answer 6

1) Valproate / Divalproex (Depakote)
2) Vigabatrin (Sabril)

Question 7

What is the MOA of Tiagabine (Gabitril) for epilepsy?

Answer 7

Inhibitor of GABA reuptake transporter GAT1

Question 8

List the 5 epilepsy meds that interact with OCPs

Answer 8

1) Lamotrigine: reduce by 50%
2) Oxcarbazepine
3) Clobazam
4) Eslicarbazepine
5) Perampanel
(all 5 decrease estrogen OCP levels)

Question 9

List the 4 epilepsy meds with minimal drug-drug interactions

Answer 9

1) Levetiracetam (Keppra)
2) Gabapentin (i think)
3) Lacosamide (Vimpat)
4) Pregabalin

Question 10

What 4 epilepsy meds are useful in comorbid bipolar disorder?

Answer 10

1) Carbamazepine (Tegretol)
2) Oxcarbazepine (Trileptal)
3) Lamotrigine (Lamictal)
4) Valproate/ Divalproex (Depakote)

Question 11

List the 10 epilepsy meds that were mentioned in class to potentially cause fetal harm

Answer 11

1) Oxcarbazepine (Trileptal)
2) Carbamazepine (Tegretol)
3) Clobazam (Onfi)
4) Cannabidiol (Epidiolex)
5) Topiramate (Topamax)
6) Lamotrigine (Lamictal)
7) Gabapentin (Neurontin)
8) Clonazepam (Klonopin)
9) Phenobarbital (Luminal)
10) Ethosuximide (Zarontin)

Question 12

List the 12 epilepsy meds that were mentioned in class to have the rare adverse effect of SJS/TEN

Answer 12

1) Oxcarbazepine
2) Carbamazepine (Tegretol): Boxed warning (for allele)
3) Lamotrigine (Lamictal): Boxed warning (for improper use)
4) Ethosuximide
5) Phenobarbital
6) Phenytoin
7) Primidone
8) Tiagabine
9) Topiramate
10) Zonisamide
11) Eslicarbazepine
12) Rufinamide

Question 13

List the 2 epilepsy meds with a boxed warning for SJS/TEN

Answer 13

1) Carbamazepine (Tegretol): for allele
2) Lamotrigine (Lamictal): for improper use/ use w. valproate

Question 14

Give examples of inducers of both CYP and UGT

Answer 14

o Phenobarbital
o Phenytoin
o Primidone
o Valproate/Divalproex

Question 15

3 anticholinergic drugs for Parkinson’s

Answer 15

1) Pimavanserin (approved for psychosis in PD)
2) Benztropine
3) Trihexyphenidyl