Imperial past papers Flashcards
Runner with irregular periods, where is problem
Hypothalamus
Features of CF
AR inheritance
Recurrent chest infections
Bronchiectasis
Pancreatic dysfunction
Small and skinny
CXR showing multiple air filled sacs in lungs
Septic emboli
Milky fluid drained from chest drain
Chylothorax- leakage of lymph fluid
Which cell is primarily affected in multiple sclerosis
Oligodendrocytes- myelin producing cells
How diagnose FH
Simon broome criteria
TC > 7.5 mmol/l and LDL-C > 4.9 mmol/l
WITH evidence of
- family member with xanthomas
- early MI
Useful blood investigations for polymyositis
Anti-Jo (anti synthetase)
CK
Management of metastatic spinal cord compression
Dex and urgent MRI
Consideration of radiotherapy or spinal surgery depending on suitability for surgery
How calculate units in alcoholic drink
%*mls divided by 1000
Management of neuropathic ulcer with black crust
Urgent referral as ischaemic
Post partum thyroiditis presentation
Thyrotoxicosis
Hypothyroid
Management of post partum thyroiditis
Thyrotoxicosis- give propanolol
Hypothyroid- thyroxine replacement
Management of graves if breastfeeding
All thionamides safe
Caseating necrosis with langerhans cells in bowel
TB
Differentials for granulomas in bowel
TB- necrotising
Crohns
What diet use for IBS
FODMAP
What is FODMAP diet helpful for
IBS
SBOSS
Sprain ankle- most likely ligament affected
Anterior tabofibular ligament
Types of chemo
- neoadjuvant
- adjuvant
- palliative
- curative
Neo- before main treatment eg surgery
Adjuvant- after main treatment
Palliative- prolong life
Curative- in name
What do if chemical injury to eye
Irrigate for 30 mins with saline then refer to opthal
When refer corneal foreign bodies to opthal
Suspected penetrating eye injury
Significant orbital or peri-ocular trauma has occurred.
Chemical injury
Foreign bodies composed of organic material
Foreign bodies in or near the centre of the cornea
Any red flags e.g. severe pain; irregular, dilated or non-reactive pupils; significant reduction in visual acuity.
Management of high cholesterol
Start on 20mg statin
Review after 3 months and assess if over 40% reduction in non-HDLc
- if not increase dose
Review after 3 months and reassess
- consider alternate agent
Choking BLS
Get to cough
If becomes ineffective or cant do, do 5 back blows
5 abdominal thrusts
If ineffective unresponsive at any point do CPR
Difficulty swallowing relieved by drinking lots of water
Pharyngeal pouch
What causes trifasicular block
Complete HB
If fluid restriction does not work for SIADH what use
Demecycline or tolvaptan
What causes production of ketones in DKA
Increased lipolysis
What monitor in refeeding
Phosphate
Man working on construction site with rats and pigeons, living in caravan nearby. Has abdo pain and nausea. Blood film showed basophilic stippling and sideroblasts. What is cause
Lead poisoning
Notifiable infections
Acute encephalitis
Acute infectious hepatitis
Acute meningitis
Acute poliomyelitis
Anthrax
Botulism
Brucellosis
Cholera
COVID-19
Diphtheria
Enteric fever (typhoid or paratyphoid fever)
Food poisoning
Haemolytic uraemic syndrome (HUS)
Infectious bloody diarrhoea
Invasive group A streptococcal disease
Legionnaires’ disease
Leprosy
Malaria
Measles
Meningococcal septicaemia
Monkeypox
Mumps
Plague
Rabies
Rubella
Scarlet fever
Smallpox
Tetanus
Tuberculosis
Typhus
Viral haemorrhagic fever
Whooping cough
Yellow fever
Pathophysiology of BBPV
Crystals of calcium phosphate in ear- otoconia
Which x ray plane best to do for c spine fracture
Lateral
What do with regards to head CT if on antiplatelets
Within 8 hours
NOT ASPIRIN MONOTHERAPY
What does SMA vs IMA supply
SMA- ampulla of vater onwards to distal 1/3 of transverse colon
IMA- Distal 1/3 of transverse colon onwards
Inheritance of BRCA
AD
How manage candida in catheter
Asymptomatic- change catheter
Symptomatic- oral fluconazole
How manage proteinuria in nephrotic syndrome
Reduce dietary protein
Give ACEi
Patient is brain dead, what determines prognosis
Brainstem reflexes
Patient has chronic RUQ pain with dilatation of intrahepatic ducts, what antibody
ANCA as PSC
Man rescured from house fire is wheezy with soot in mouth and nose what give
100% oxygen (worried about CO poisoning)
How feed a patient with a prolonged postoperative ileus
IV parenteral feeding
Woman with history of radiation for cervical cancer presents with continuous dribbling of urine
Vesicovaginal fistula
First line investigation for suspected laryngeal cancer
Flexi-nasoendoscopy
Which substance is the primary factor facilitating platelet adhesion?
VWB factor
A 50 year old woman has suddenly become short of breath. She has found it painful to swallow for two months, and she has coughed up a small amount of blood. She is distressed and cannot lie flat.
Her temperature is 37.5°C. Her respiratory rate is 40 breaths per minute and her oxygen saturation is 78% using 15L pe minute via a re-breather mask. She has inspiratory stridor.
What is the most appropriate action to take?
Continuous positive airways pressure ventilation
Endotracheal intubation
Nebulised bronchodilators
Oral airway
Tracheostomy
Endotracheal intubation
What scan use to plan surgery on ankle fracture
CT
A 70 year old woman is admitted with a one week history of worsening breathlessness. She looks pale. She has a temperature of 36.2°C, pulse rate 100 bpm, BP of 132/68 mmHg, JVP +8 cm above the sternal angle and oxygen saturation 94% on 40% oxygen via a face mask. She has bilateral inspiratory crepitations to the midzones. She has a pansystolic murmur at the apex.Investigations:
Haemoglobin 52 g/L (115-150)
MCV 120 fL (80-96)
White cell count 3.0 x 109/L (3.8-10.0)
Platelets 87 x 109/L (150-400)
Which is the most likely diagnosis?
Acute myeloid leukaemia
Alcoholic cardiomyopathy
Hypothyroidism
Pernicious anaemia
Viral myocarditis
Pernicious anaemia
Think HF due to anaemia
Mitral regurg can be a result of HF
Pernicious anaemia would give the very high MCV and pancytopenia
First thing do if patient develops signs of transfusion reaction
Stop
ABC
Check details
If develop raised ALT as IVDU what is most likely cause
Hep C- incidence higher in IVDU
A 19 year old man has 3 weeks of diarrhoea. He is a student and has just returned from a gap year in Thailand.
Investigations:
Haemoglobin 96 g/L (130-175)
MCV 76 fL (80-96)
Eosinophils 3.1 x 109/L (0-0.4)
Which is the most likely diagnosis?
Amoebiasis
Campylobacter
Hookworm
Shigellosis
Typhoid fever
Hookworm
Causes IDA and also as parasite will cause eosinophillia
For protozoa like amoeba would not cause eosinophillia
What is trendelenburg manoeuvre
Where position patient lying down with head beneath body
Blood film shows smear cells what is next investigation
Immunophenotyping with flow cytometry
How best diagnose giardia
Stool sample will see parasites
Patient comes in unstable with blood diarrhoea on history of IBD like symptoms, what do next
CT
X rays going out of fashion
What is preferred test nowadays for H pylori
Faecal antigen test
If HBe IgG what does this mean
NOT that necessarily actively replicating, just that previous infection
How diagnose Hep D
Anti Delta IgM
Thyroid cancer of parafollicular (C) cells
Medullary
How investigate RAS
MR/CT angio
How treat RAS
If very problematic then percutaneous renal artery angioplasty
How differentiate inferior vena cava obstruction from portal HTN
Look at vein underneath umbilicus and which direction blood is flowing
IVCO- blood flow upwards
Portal HTN- blood flows towards feet
SNAPP causes
Sulphonamides
NSAIDS
Allopurinol
Penicillin
Phenytoin
Most likely cause of amaurosis fugax
Cholesterol deposit emboli
If LP shows positive SAH what do next
CT angio
When give thiamine for seizures
Alcoholic
Malnutrition
Give straightaway in initial period before benzos
Most likely cause of medical third nerve palsy
DM
If third nerve palsy with dilated pupil only what must ensure do
Urgent imaging
If unstable UC presentation what is first thing do
CT abdomen
X rays not recommended anymore
What give for fluids refractory septic shock
Vasopressors- noradrenaline etc
When say consider stopping in AKI what is reasoning behind this
They are drugs which will accumulate and lead to toxicity if renal function is poor
When monitor CVP
Do on ITU
Helps tailor dose of inoptropes and vasopressors when treating shock
What do for AF incidentally picked up with no symptoms and normal HR
Just give DOAC
What use for AF if valvular disease
Warfarin
If cardiogenic shock from cardiac tamponade what use
Fluids
Inotropes will not work
If pericardiocentesis resistant cardiac tamponade what use to treat
Pericardial window
If someone is completely unable to take any anticoagulation what do for stroke risk in AF
Can insert left atrium appendage occlusion device
Does VT within 1 week of MI require ICD
No as very common then
What investigation do if raised troponin and angiogram normal
Cardiac MRI
Will help give idea of fibrosis/local damage to cardiac tissue
Most common site of AF impulse initiation
Pulmonary veins
What can be seen on CXR of mitral stenosis
Small nodules around lungs from haemosiderin depostion as pulmonary HTN has lead to haemolysis