Immunology Flashcards
Target of bevacizumab
Anti VEGF (anti angiogenic)
Where should adrenaline be given anaphylaxis
Anterolateral part of middle third of thigh
What are different types of venom allergy
Local- redness around area, all sx localised to bite
Systemic- reactions distant to site related to histamine release ie widespread pruritus, lip swelling, abdo pain and vomiting
Anaphyaxis
Symptoms of a systemic venom allergy
cutaneous reactions that are relatively distant from the exposure site e.g. widespread redness, itching, urticaria and/or angioedema (not affecting the mouth or throat).
What is management of venom allergy
If anaphylaxis, adrenaline etc
Local/systemic- antihistamines, supportive
If systemic referral to allergy clinic
What do if history of systemic venom allergt
Refer to allergy clinic for testing
Management of refractory anaphylaxis
Seek expert guidance
IV adrenaline and IV fluid bolus
Presentation of behcets
Oral ulcers
Genital ulcers
Uveitis
See VTE too in behcets
What muscle is adrenaline injected into in anaphylaxis
Vastus lateralis
Features of takayasus
systemic features of a vasculitis e.g. malaise, headache
unequal blood pressure in the upper limbs
carotid bruit and tenderness
absent or weak peripheral pulses
upper and lower limb claudication on exertion
aortic regurgitation (around 20%)
Management of takayasus
Steroids
Investigations for takayasus
MR or CT angio
Presentation of aortic coarctation
Infancy- heart failure
Adults- HTN
Features on examination of aortic coarctation
Radio-femoral delay
HTN
Mid systolic murmur heard loudest at the back
Notching of inferior ribs
