Immunotherapy simple

Question 1

advent of immunotherapy

Answer 1

technique had limited application until the advent of hybridoma technology

Question 2

production of mABs renewed interest in

Answer 2

targeting tumour for diagnoses and therapy

Question 3

detection of tumour-associated antigens offers an

Answer 3

attractive target for radioisotopes and other substances for mAbs to carry to tumour

Question 4

mAbs can be used in

Answer 4

treatment or imaging

Question 5

thee types of immunotherapy

Answer 5

• passive vaccination
• immune checkpoint modulation
• immune cell therapy

Question 6

passive vaccination

Answer 6

therapeutic mAbs

Question 7

passive vaccine methods

Answer 7

1) carry cytotoxic agent to tumour
2) indue complement mediated lysis or ADCC of tumour cell
3) block activity of tumour specific proteins (Perception)

Question 8

tumour specific protein

Answer 8

herceptin

Question 9

ways of targeting tumour cells with mAbs

Answer 9

1) naked mAb
2) immunoconjugated mAb
3) multistep targeting

Question 10

naked mAb

Answer 10

ADCC

Question 11

immunoconjugated e.g.

Answer 11

radioimmunoconjugated
immunomoxin
prodrug- drug
immunoliposome
cellular immunoconjugates

Question 12

antibody guided chemotherapies

Answer 12

use of radioisotopes, drugs, toxins conjugated to monoclonal antibody targeted to cancer cells

Question 13

example of a chemotherapeutic agent

Answer 13

Cisplatin

Question 14

toxins used

Answer 14

Diphtheria, Ibrin and Ricin