Immunotherapy examples Flashcards
therapeutic monoclonal antibodies can be used to treat
- Non hodjkins lymphoma
- Breast cancer
- Alzheimers
Non Hodgkins Lymphoma is a
malignant growth of b cells that result in tumours in lymph nodes and throughout the body
how many americans affected by NHL
250,000
cure for NHL
no cure for most patients
how many patients with NHL treated with radiation and chemotherapy are alive after 5 years
60%
Betsy Patterson
34 year old diagnosed with NHL
after 9 years (Betsy)
tumour filed lymph nodes appear and she is enter 9-month phase II clinical trial with two chemotherapeutic drugs
name the two chemotherapeutic drugs
Fludarabine and mitoxanthrone
side effects of chemo drugs
vomiting, nausea, oversies stop producing hormones (premature menopause, night sweats and physical change)
drugs administered to control nausea
leads to drowsiness- bed ridden 22 h a day
what does betsy develop
diabetes, severe folic acid deficiency, anaemia and nerve damage
18 months after chemotherapy
return of NHL
betsy is then treated with
Rituximab
Rituximab was the
first monoclonal antibody treatment approved for cancer
what type of antibody is rituximab
chimeric
rituxmab is also known as
rituxan
rituxan targets
CD20
CD20 is an antigen
present on the surface of neoplastic B cells
what does rituximab consist of
a human IgG antibody with mouse variable regions
how does rituximab lyse CD20 cells
using human complement or ADCC
after two weeks of treatment with rituximab
chest pains from swollen lymph nodes disappear
after one months
35% reduction in the tumour
- nodes in back of neck have completely disappeared
toxicity associated with rituximab
non
colombat 2001 paper regarded
a clinical and molecular evaluation of rituximabe
