Immunotherapy Flashcards
Goals of immunotherapy?
- boost immune system and train it to attack specific cancer cells
Cancer cells alter gene expression and regulate protein production in order to evade destruction by ___
TILs
Types of Immunotherapies:
- immune checkpoint inhibitors
- T cell transfer therapy
- Monoclonal abs
- Tx vaccines
- Immune system modulators
Types of anti-tumor immunotherapies:
- cancer vaccines
- adoptive vaccines
- immunomodulation
which immunotherapy improves T cells ability to detect and destroy cancer cells?
cancer vaccines
______ increases quantity and and activity of T cells
adoptive immunotherapy
______ increases immune system activity and decreases immune system inhibition
Immunomodulation
_____ normally fxn to prevent hyperstimulation and overtly strong immune responses by interacting w/ partner protein and turning T cells off
Immune checkpoint proteins
What inhibits partner protein interaction and causes T cell to be active to kill cancer cells?
immune checkpoint inhibitors
Which immune checkpoint protein is mostly in LNs and binds B7 w/ greater affinity which results in anergy?
CTLA-4
Tx for CTLA-4 is..?
anti-CTLA-4–> T cells activated
Which immune check point protein is mostly in peripheral tissues and is expressed by chronically “tired” T cells?
PD-1
PD-1 binds _____ in order to suppress T cell fxn, proliferation, cytokine production (IL-2)
PD-1 binds PD-L1/PD-L2
(T/F) Immune checkpoints are a normal part of the immune system
TRUE
CTLA-4 and PD-1 binding decreases cytokine proliferation, including interferon- ____ and _____
IFN-g and IL-2
Fever, malagias, multiple organ dysfxns, pleural effusion, coagulopathy due to a boosted immune response describes?
Cytokine release syndrome
Mediating cytokines in cytokine release syndrome?
IL-6, IL-10, IFN-g, TNF, IL-2
what is a side effect of chimeric antigen receptor T cell immunotherapy?
cytokine release syndrome
Side effect of TIL therapy?
Systemic Capillary Leak syndrome (clarkson’s syndrome)
Condition in which fluid and protein extravasation occurs from circulatory system to peripheral tissues and is mediated by cytokines?
capillary leak syndrome
Tx for cap. leak syndrome?
-fluid and blood replenishment
- IVIG
no tx tho
cap. leak syndrome leads to..?
hypotension, hypoalbuminemia, hemoconcentration
