Immunotherapy

Question 1

Goals of immunotherapy?

Answer 1

• boost immune system and train it to attack specific cancer cells

Question 2

Cancer cells alter gene expression and regulate protein production in order to evade destruction by ___

Answer 2

TILs

Question 3

Types of Immunotherapies:

Answer 3

• immune checkpoint inhibitors
• T cell transfer therapy
• Monoclonal abs
• Tx vaccines
• Immune system modulators

Question 4

Types of anti-tumor immunotherapies:

Answer 4

• cancer vaccines
• adoptive vaccines
• immunomodulation

Question 5

which immunotherapy improves T cells ability to detect and destroy cancer cells?

Answer 5

cancer vaccines

Question 6

______ increases quantity and and activity of T cells

Answer 6

adoptive immunotherapy

Question 7

______ increases immune system activity and decreases immune system inhibition

Answer 7

Immunomodulation

Question 8

_____ normally fxn to prevent hyperstimulation and overtly strong immune responses by interacting w/ partner protein and turning T cells off

Answer 8

Immune checkpoint proteins

Question 9

What inhibits partner protein interaction and causes T cell to be active to kill cancer cells?

Answer 9

immune checkpoint inhibitors

Question 10

Which immune checkpoint protein is mostly in LNs and binds B7 w/ greater affinity which results in anergy?

Answer 10

CTLA-4

Question 11

Tx for CTLA-4 is..?

Answer 11

anti-CTLA-4–> T cells activated

Question 12

Which immune check point protein is mostly in peripheral tissues and is expressed by chronically “tired” T cells?

Answer 12

PD-1

Question 13

PD-1 binds _____ in order to suppress T cell fxn, proliferation, cytokine production (IL-2)

Answer 13

PD-1 binds PD-L1/PD-L2

Question 14

(T/F) Immune checkpoints are a normal part of the immune system

Answer 14

TRUE

Question 15

CTLA-4 and PD-1 binding decreases cytokine proliferation, including interferon- ____ and _____

Answer 15

IFN-g and IL-2

Question 16

Fever, malagias, multiple organ dysfxns, pleural effusion, coagulopathy due to a boosted immune response describes?

Answer 16

Cytokine release syndrome

Question 17

Mediating cytokines in cytokine release syndrome?

Answer 17

IL-6, IL-10, IFN-g, TNF, IL-2

Question 18

what is a side effect of chimeric antigen receptor T cell immunotherapy?

Answer 18

cytokine release syndrome

Question 19

Side effect of TIL therapy?

Answer 19

Systemic Capillary Leak syndrome (clarkson’s syndrome)

Question 20

Condition in which fluid and protein extravasation occurs from circulatory system to peripheral tissues and is mediated by cytokines?

Answer 20

capillary leak syndrome

Question 21

Tx for cap. leak syndrome?

Answer 21

-fluid and blood replenishment
- IVIG
no tx tho

Question 22

cap. leak syndrome leads to..?

Answer 22

hypotension, hypoalbuminemia, hemoconcentration