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Immunology > Active & Passive Immunity (Davis) > Flashcards

Active & Passive Immunity (Davis) Flashcards

1
Q

(T/F) you make abs in passive immunity

A

FALSE; you are receiving abs from another source

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2
Q

Immediate protection, short-lived immunity, and no memory describe..?

A

passive immunity

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3
Q

Natural passive immunity includes:

A
  • passage of abs from mother to fetus

Placenta (IgG) and colostrum (IgA)

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4
Q

Artificial passive immunity involves passage of pre-formed abs to recipient through a..?

A

a serum

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5
Q

examples of artificial passive immunity?

A
  • human immune serum globulin
  • hyper-immune/convalescent serum
  • antitoxin/antivenom
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6
Q

(T/F) You make abs in active immunity after being exposed to an antigen

A

TRUE

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7
Q

Delayed protection and long-term immunity describe what type of immunity?

A

active

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8
Q

Example of artificial active immunity?

A

vaccines

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9
Q

Minimum threshold to achieve herd immunity is based on:

A

Infectivity of the pathogen (Ro)

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10
Q

(T/F) Vaccine should mimic natural pathogen as close as possible and stimulate immune response to develop abs and immunological memory w/o risk of infxn

A

TRUE

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11
Q

Vaccine route that’s developed for GI tract but the downside is the acidity of the stomach may destroy vaccine antigen and prevent immune response?

A

oral route

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12
Q

Which vaccine route is used for respiratory infxns and stimulate a strong IgA response?

A

Nasal

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13
Q

What’s the best vaccine route that involves the abundance of DCs which allow the antigen to be processed and presented to stimulate immune response?

A

Intramuscular

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14
Q

Antigen will ____ in muscle–> increased longevity in muscle due to slower absorption–>increased exposure time–> increased length of immune response–> develop IgG abs, memory

A

precipitate

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15
Q

which vaccine route causes a rapid immune response and has decreased likelihood of developing strong immune response..?

A

IV route

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16
Q

what is a live attenuated vaccine?

A

the antigen is a modified form of natural pathogen that’s developed to be non-pathogenic but retains immunologic stimulating properties

17
Q

Benefit of a live attenuated vaccine?

A

mimics actual infxn–> stronger immunological response

18
Q

CI for live attenuated vaccines:

A
  • children <12 y/o

- immunocompromised ppl (vaccine can revert back to infective form)

19
Q

Results of a live attenuated vaccine?

A
  • develop CMI and Humoral immunity
  • effective for IC pathogens
  • usually one dose effective
20
Q

Types of inactivated vaccines include:

A
  • killed whole cells
  • Fractional;protein
  • Fractional; polysaccharide
  • Reassortment
  • Recombinant vector
  • DNA
21
Q

what type of vaccine consists of the incomplete form of pathogen or dead pathogen and only elicits humoral response (EC pathogens)?

A

Inactivated vaccines

22
Q

(T/F) Inactivated vaccines typically require multiple doses & boosters

A

TRUE

23
Q

(T/F) Inactivated vaccines have NO contraindications to getting multiple vaccines simultaneously except if someone has an allergy

A

TRUE

24
Q

Decreasing the time interval may interfere w/ the immune response w/ which types of vaccines?

A

Inactivated vaccines

25
Q

___ are (human) pooled abs for those who are immunocompromised

A

IVIG

26
Q

_____ immunoglobulin is used for thymic transplants to reduce rejection

A

Antithymocyte

27
Q

____ is used for prevention and tx of infxn and death caused by anthrax

A

Obiltoxaximab

28
Q

___ immune globulin should be given before or within 2 weeks of exposure

A

HepA and HepB

29
Q

___ immune glbulin is a live vaccine given within 6 days of exposure

A

Measles

30
Q

___ is given along w/ the rabies vaccine series

A

Rabies virus inactivated antigen vaccine

31
Q

_____ is given for Rh incompatibility

A

RhoGAM

32
Q

_____ is given to infants < 6 moa in the hospital where RSV is occuring or in children <24 moa w/ breathing problems or a hx of premature birth

A

RSV-IGIV

33
Q

___ is a monoclonal ab given to children <24 moa at the beginning of RSV season

A

Synagis

Immunology (10 decks)

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