Autoimmune Disease

Question 1

2 ways that autoimmune diseases can develop:

Answer 1

1. failure to develop tolerance to self-antigen

2. dysregulation of part of the immune system leads to loss of tolerance to self

Question 2

Factors that contribute to autoimmune disease?

Answer 2

genetics, infectious agents, anatomic alterations- injury

Question 3

molecular mimicry is when..?

Answer 3

when the epitope of an infxn agent is the same as self

Question 4

ex of molecular mimicry?

Answer 4

rheumatic fever (s.pyogenes)

Question 5

organ specific dz?

Answer 5

MG, Hashimotos, Graves, IDDM

Question 6

what disease is due to IgM-IgG immune complex deposition in joints?

Answer 6

rheumatoid arthritis

Question 7

type III disease due to ANAs developing against intracellular targets?

Answer 7

SLE

Question 8

what disease is mediated by T cell attacks on nerve tissues and maybe be a result of demyelination or bystander damage?

Answer 8

MS

Question 9

What stimulates inappropriate activity and leads to over production of products made by the organ or increase in cell growth?

Answer 9

agonistic ab

Question 10

What block organ fxn and leads to impaired production of products produced by the organ or atrophy of tissues?

Answer 10

antagonistic ab

Question 11

disease involving an antagonistic ab made against Ach receptors on motor end plates of muscles?

Answer 11

MG

Question 12

Late stage of MG is attributed to:

Answer 12

Ab and complement-mediated damage to the NMJ

Question 13

disease resulting from ab made against thyroid proteins involved in the uptake of iodine that results in hypothyroidism?

Answer 13

Hashimotos thyroiditis

Question 14

disease that involves an agonistic ab made to T-SHIRT receptor and causes hyperthyroidism?

Answer 14

grave’s disease

Question 15

Disease that involves CTLs infiltrating the islets of Langerhans and damage insulin-producing cells via release of cytokines?

Answer 15

Type I DM