Humoral Immunity (Waziry) Flashcards
IgM function,,?
BCR (w/ IgD) on naive B cells, secreted IgM mainly in the circulation, first antibody class produced in the adaptive response, activates complement, powerful agglutinin
Which antibody is the most abundant in circulation, activates complement, enhances phagocytosis, ADCC, neutralizes pathogens, and crosses placenta?
IgG
Which antibody has a secretory form that prevents colonization at mucosal surfaces?
IgA
Which antibody is on BCR on naive B cells along w/ IgM ?
IgD
Which antibody in the presence of antigens, triggers the release of inflammatory mediators from mast cells and basophils?
IgE
what does neutralization do?
prevents pathogen-host binding
Main neutralizing antibody in blood?
IgG
What do opsonizing antibodies do?
they coat the target, identifying it for destruction or removal by other immune cells
Opsonization depends on?
depends on the ability of the constant region to interact w/ Fc receptors on other cells
what are Fc receptors found on?
macrophages, neutrophils, eosinophils, DCs, & NK cells
Bound Fc receptors signal the cell to do what?
to kill and degrade the ingested particle via oxidative burst
(T/F) antibodies are the only soluble factor that can opsonize pathogens
FALSE
Opsonization can also be carried out by ___ and ____ which are produced by innate complement pathway & can help remove pathogens before adaptive response is available!
C3b and C4b
Once the humoral response is activated, what will be produced in order to activate the classical cascade?
IgM
What occurs when C1 binds to 2+ antigen-bound antibodies?
The complement cascade is triggered, forming the MAC
ADCC can be mediated by:
IgG, IgA and IgE
ADCC is mainly carried out by:
NK cells, neutrophils, macrophages, and eosinophils
Eosinophils express high affinity Fc receptors for which antibodies in order to opsonize helminths?
IgE
NK cells express low affinity Fc receptors for which antibodies in order to opsonize infected cells?
IgG
__ response is when innate response cells fill in the gap while adapted response is mounted
Primary response
___ response involves innate and adaptive working together right away!
secondary response
Which antibody is predominant in primary response? what about secondary response?
IgM-primary
IgG- secondary
What does the lag/latent phase entail?
initially, antigen is presented and lymphocytes are activated–> activated B and T lymphocytes undergo proliferation/differentiation
(T/F) no detectable level of antibody in serum during lag phase
true
What does the log phase entail? (this is what we measure)
plasma cells secreting antibodies, serum antibody levels increase
What does the plateau phase entail?
antibody titer is at its peak
What does the decline phase entail?
plasma cells begin to die and antibody titer begins to decline as less antibody is made
T-dependent responses can be categorized as either ___ or ____
primary or secondary
No T-cell involvement, no CD40-40L interaction, dominated by IgM, no memory B cell development, and lower antibody titers all describe what type of response?
T-independent responses
