Immunosuppressants

Question 1

Prednisolone

Answer 1

Auto-immune disease and transplantation
Glucocorticoid
Binds to the glucocorticoid receptor in cytosol
Side effects: moon face, hypertension, diabetes, osteoporosis

Question 2

Dexamethasone

Answer 2

Auto-immune disease and transplantation
Glucocorticoid
Binds to glucocorticoid receptor in cytosol
Side effects: moon face, hypertension, diabetes, osteoporosis

Question 3

Azathioprine

Answer 3

Auto-immune disease
Antimetabolite
Purine antagonist
Side effects: nausea, vomitting, skin rash, malignancies, anemia, infections

Question 4

Mycophenolate mofetil

Answer 4

Auto-immune disease and transplantation
Antimetabolite
IMP dehydrogenase
Side effects: GI, leukopenia, anaemia

Question 5

Chloroquine

Answer 5

Auto-immune disease
Antimalarial
Immune suppression for SLE
Side effects: mood changes, GI, retinopathy, cardiac toxicity

Question 6

Cyclophosphamide

Answer 6

Auto-immune disease
Alkylating agent
Side effects: nausea, haemorrhagic cystis, diorrhoae, lethargia, darkening of the skin/nails, hair loss

Question 7

Everolimus

Answer 7

Transplantation
mTOR inhibitor, inhibits IL-2 mediated signal transduction
Side effects: anemia, leukopenia, throbocytopenia, GI, hyperlipidemia, proteinuria

Question 8

Basiliximab

Answer 8

Transplantation
Antibody
Il-2 antagonism
Side effects: GI, metabolic effects, headache, tremor, hypersensitivity

Question 9

Alemtuzumab

Answer 9

Transplantation
Antibody
Binds to CD52 on lymphocytes
Side effects: hypotension, rigors, fever, shortness of breath, bronchospasm, rash