Diseases

Question 1

Myasthenia gravis

Answer 1

Antibodies directed agains AchR, MuSK, Lrp4
Weakness begins cranial
Associated with thumoma

Question 2

MG MuSK antibodies

Answer 2

problems with speech, swallowing

weakness of neck musculature

Question 3

MG AChR antibodies

Answer 3

Most abundant

fluctuating ptosis and oftalmoplegia

Question 4

Lambert Eaton Myasthenic Syndrame (LEMS)

Answer 4

Antibodies directed against VGCC’s
Weakness starts in legs, ascending
Associated with lung cancer SCLC

Question 5

Henoch-Schonlein purpara

Answer 5

Mainly affecting skin and gut
Purpura
IgA deposits in skinbiopt
No ANCA

Question 6

Churg Strass syndrome

Answer 6

Vasculitis of lung with eosinophilic infiltrate
Patients previously known with asthma
Anti-MP antibodies (p-ANCA)

Question 7

Granulomatosis with polyangiitis (GPA)

Answer 7

Upper airway vasculitis
Renal involvement, presences of granuloma’s
Saddle nose
anti-Pr3 antibodies (c-ANCA)

Question 8

RA

Answer 8

Influx of neutrophils, plasma cells

ACPA auto-antibody

Question 9

Pemphigus vulgaris

Answer 9

Blistering of the skin, simular to MuSK MG

Question 10

Post transplant Lymphoproliferative disorder

Answer 10

Uncontrolled proliferation of B cells latently infected with EBV
Immunosuppressed patients lack Treg

Question 11

Usual Interstitial Pneumonia (UIP)

Answer 11

Most occuring IPF
Diffuse long fibrosis, starting subpleural
Spotty distribution
Lung damaged by several hits
Clear border 
Prognosis three years

Question 12

Nonspecific interstitial pneumonia (NSIP)

Answer 12

Diffuse fibrosis in alveoli
Interstitial fibrosis
Lung damaged by one hit
Prognosis twelve years

Question 13

Grave’s disease

Answer 13

Auto-immune disease

Hypertyroidism