Functions of IL, Factors etc

Question 1

Factor P

Answer 1

stimulation and stabilisation of C3 convertase

Question 2

Factor H/I

Answer 2

Inhibits forming of MAC

Question 3

IL-6

Answer 3

causes synthesis of …. in liver:

• CRP
• MBL
• C3,C4,C9 factor B
• Fibrinogen

Question 4

Type I interferon

Answer 4

proliferation and differentation of NK cells

Question 5

Bradykinin

Answer 5

Increase of vascular permeability

Question 6

Increase of temperature by

Answer 6

IL-1, IL-6 and TNFalfa

Question 7

Lipofuscine

Answer 7

Waste product of lysomal digestion

Question 8

Th0

Answer 8

naive T cell, either CD4 or CD8

Question 9

Th

Answer 9

helper cell, CD4

Question 10

Th1

Answer 10

cell mediated response against intracellular bacteria and protozoa
regulation of monocytes and macrophages
triggered by IL-12
Effector: IFN gamma and IL-2

Question 11

Th2

Answer 11

Humoral immune response against extracellular parasites
regulation of eosinophils, basophils and mast cells
triggered by Il-2 and IL-4
Effector: IL-4, IL-5, Il-9, IL-10,IL-13,IL-25

Question 12

Th17

Answer 12

neutrophilproduction and recruitment
regulation of neutrophils
triggered by TGFbeta, IL-6, IL-21, IL-23
Effector: IL-17

Question 13

IL-12

Answer 13

Th0 –> Th1

Anti-angiogenic activity

Question 14

IL-2

Answer 14

Tho –> Treg (thereby preventing autoimmune disease)

Th –> Th1/Th2

Question 15

IFN gamma

Answer 15

Activates macrophages

Induces expression of MHCII

Question 16

IL-4

Answer 16

Th0 --> Th2
B cell class switching to IgE

Question 17

Il-5

Answer 17

B cell growth

Increases IgA secretion

Question 18

IL-6

Answer 18

Increased body temperature
Stimulation of osteoclast
Production of neutrophils in bone marrow
Growth of B cells

Question 19

IL-9

Answer 19

stimulates cell proliferation

prevents apoptosis

Question 20

TNF alfa

Answer 20

Local tissue destruction

Increased expression of adhesion molecules in blood vessels

Question 21

Il-3

Answer 21

Enhanced production of monocytes in bone marrow