immunosuppresant drugs Flashcards
1
Q
cyclosporin
- MOA
- SE
A
- bind to cyclosporins in t cells –> inhib calcineurin –> inhib IL2
- SE
- viral infections
- lymphomas
- nephrotox, HTN
2
Q
tacrolimus and permercrolimus
- MOA
- SE
A
- bind FKBP –> inhib calcineurin –> inhib IL2
- SE:
- nephrotox, HTN
- neurotox
3
Q
azathroprine
- MOA
- used in
- SE
*
A
- (precursor to 6 mercaptone)
- interfere w NA synth –> cells not divide/prolif
- used in kidney transplan, RA
- SE: BM suppression, metabolized by XO
4
Q
sirolimus
- MOA
A
- binds FKBp12 –> inhib mTOR –> inhib T cell prolif –> cant resopnd to IL2
5
Q
mycophenolate
- MOA
- use
- SE
A
- inhibs INP dehyderogenase –> inhibs guanine synth –> prevent lymphocyte prolif
- transplants, lupus nephritis
- hyperglycemia, hypercholesterolemia, HTN, infxn, lymphoma
6
Q
thalidomide
- MOA
- uses
- SE
A
- suppress TNF-a prod, increase NK cells and I-2
- erythema nodosum leptosum (hansen dis), MM
- phocomelia
7
Q
Infliximab ad adalumab
- MOA
- uses
A
- bind/inhib TNFa
- used in sero- spondyloarth and RA
8
Q
abciximab
- MoA
- uses
A
- against 2-3-b-a receptor on plts
- if cardiac stent, MI, angina
9
Q
Trantuzumab
- moa
- uses
A
- against ERBB3
- BRCA w HER2
10
Q
etanercept
- moa
A
- mimics TNFa receptor= takes up all the agonists
11
Q
Rituximab
- moa
- use
A
- binds CD20 –> compliment to lyse B cell
- NHL
12
Q
Omalizumab
- moa
- uses
A
- against IgE
- asthma
