4/5 star topics DIT Flashcards
RA
- charas of joint
- abs
- presentation
- tx acute
- tx long-term
- joints: hand, wirst, elbow, knee, post knee, ankle/forefoot/subtalar, upper cervical
- synovium overgrows bone (pannus), rheum nodules,
- RF (IgM agains IgG), anti-citrinulated protein ab
- morning stiffness, imporve w use, symm, symmetric, systemic (fever, fatigue, pleural effusion, pericarditis)
- acute: NSAIDs, COX2 inhib, steroids
- long: DMARDs: MTX, hydrdroxychoroquine, sulfasalazineTNFa inhibs (enteracept, infilximab, adalumumab, golinumab, certulizumab
components fo tetralogy of fallot
- RV outflow tract obs (pulm stenosis)
- RV hpertrophy
- VSD
- overriding aorta
**looks like boot shaped <3**
chronic mucocutaneous candidiasis
- how aries
- tx
- t cell dysf
- ketoconazole
chediak higashi synd
- pathogenesis
- s/s
- defectice LYST gene –> defective phagocyte lysosomes –> giant cytoplasmic granules in PMNs
- triad: (PAIN)
- partial abinism
- recurrent respiratory tract and skin infxns
- neuro disorders
aortic regurg
- location
- systolic or diastolic
- assoc w:
- d/t:
- pic
- L sternum
- diastolic
- wide pulse pressure (water-hammer pulse - bounding peripheral); head bob
- aortic root dialtion (syphilis, marfans), BAV, RF

diffs btwn scc, bcc, melanoma of skin
squamous:
- sun exposed
- scaly plaque, ulcerative red lesion
- keratin pearls
basal:
- sun exp
- roleld edge
- central nuc
- pearly
- telangiectasias
- palasadig nuclei
melanoma:
- s-100 marker
- depth ~ mets
- Asymm, Border, Color, Diameter
- melanocytes in epidermis
- neurotoxin:
- what?
- which prod?
- enterotoxin:
- what?
- which prod?
- super antigens:
- what?
- which prod?
- neurotoxin:
- interfere w neural transmission
- botulinim, tetanus
- enterotoxin:
- affect intestines
- shigella, cholera
- super antigens:
- simult bind MHC2 and t cell receptor –> t cell expansinon –>cytokines
- staph a and strep pyogenes
- label Vmax, 1/2Vmax, Km, and the velocities on a MM graph
- label x and y int on L-B plot
- how do these change with competitive and noncompetitive inhibitors
pgs 136-& DIT
label the parts of the pressure-volume loop for the <3 and how does incraesed preload, afterload, and contractility affect it
selective immunoglobulin deficiencies - IgA deficinecy
- s/s
- appear healthy, but sinus and lung infxns, atopy, asthma, anaphylaxis to blood trnsfusions and blood prods
delirium vs dementia:
- onset
- daily course
- level of consciousness
- thought production
- psychotic features
- prognosis
label the circle of willis and the the fuctions that the aca, mca and pca supply
pg 38 dit
what are the m’s that compose the rotator cuff and what are their fcts
- supraspinatus - initial 15deg abd shoulder
- infraspinatus - ext rotation
- teres minor - ext rotation
- subscapularis - inernal rotation
hemispatial neglect synd
=parietal cortex lesion of nondominant gyrus
–> results in neglect of body or surroundings c/l to lesion
DiGeorge Synd
- how arise?
- s/s:
- genetics
- no 3/4 pharyngeal pouch
- no thymus –> no mature t cells
- no parathyroids –> decr PTH –> hypocalcemia, tetany
- ss
- viral, fungal, protozoal infxns
- heart, great vessel defect
- 22q11 deletion
hyper IgE synd (Job)
- pathogenesis
- s/s
- mutation STAT3 –> impaired Th17 diff and recruitment of nfs; also high legesl IgE and eos
- triad
- czema
- cold staph a abcess
- course facial features: broad nose, prominent forehead, deep eyes, doughy skin
- (also 2 rows teeth)
what structures come from neural crest cells?
MAGIC COPS -melanocytes -aorticopulmonary septum -ganglia: autonomic, dorsal root, enteric (PNS!) -iris stroma -chromaffin cells -CNs -odontoblasts and ossicles -parafollicular (C) cells -sclerae
mitral stenosis
- location
- systolic or diastolic
- what you hear
- heard best when
- d/t:
- pic
- apex
- diastolic
- opening snap
- L lat decubitus; expiration
- RHD ==> scarring

Gerstmann synd
= a parietal cortex lesion of the dominant angualr gyrus resulting in:
- agraphia
- acalculia
- R-L disorientatio
- finger agnosia
patent ductus arteriosus
- systolic or diastolic
- what sound like
- diastolic
- machine like
what drugs increase contractility
chatecholammies (B1 agonists)
VSD
- systolic or diastolic
- who has?
- systolic
- newborns

Kleinfelter synd
- genes
- presnet
- hormones
- 47 XXY
- testiculr atrophy –> decr T, less musc body, less facial hair, broad hips, tall, long ext, gynecomastia, F hair distrib, reduced fertility
- decr inhibin, incr FSH








