IMMUNOSEROLOGY Flashcards
Predominant Ig in healthy human serum – this antibody has longest circulation life
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
E
Predominant Antibody in the secondary/anamnestic secondary response
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
E
Provides immunity to the newborn
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
E
the only antibody that can cross the PLACENTA
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
E
Only___________ can actively cross the placenta
IgG1 and IgG3
Most potent to least potent IgG
IgG 3, IgG 1, IgG 2
BEST PRECIPITATING ANTIBODY
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
E
Small size antibody – can diffuse semi-solid medium
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
E
Considered as warm reacting antibody
Can optimally react @ 37°C
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
E
Always considered as clinically significant.
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
E
Considered as the biggest antibody – pentameric antibody (5 monomers)
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
D
Predominant antibody in the primary immune response and in the acute stage of disease
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
D
First to appear phylogeny and last to leave in senescence
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
D
It has J chain
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
A and D
Cold reacting antibody
Optimal temperature is 4°C
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
D
Most potent antibody that can fix complement protein
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
D
Considered as the BEST AGGLUTINATING ANTIBODY
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
D
First antibody to be expressed on the surface of B cells, because the Mu heavy chain is the First heavy chain to be synthesized in the B
cells
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
D
Exist as MONOMER and DIMER; It has 2 forms
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
A
Responsible for mucosal immunity against microbial agent that enters the body through mucosa/skin
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
A
The only antibody with secretory component
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
A
Can also be transferred from mother to the baby through the colostrum (breast milk)
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
A
Function is still unknown but believes to play a role in immunoglobulin
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
C
Found on the surface of B-lymphocytes
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
C
Second antibody to be displayed on the surface of B-cells; second to IgM
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
C
Postulated to be an anti-idiotypic antibody
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
C
Can attack the variable region
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
C
Least abundant antibody Ig in the serum
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
B
Heat-labile antibody, originally known as Reaginic antibody
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
B
Only antibody that can binds strongly to mast cell and basophil receptor – the only antibody with specific receptor
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
B
Mediates some types of hypersensitivity reactions
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
B
The release of the histamine is due to the binding of IgE with an attached allergen
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
B
Increased in parasitic infection and helminth infection
a. IgA
b. IgE
c. IgD
d. IgM
e. IgG
B
Also known as anaphylactic hypersensitivity
Type 1
Also known as antibody-mediated cytotoxic
Type 2
Also known as complex-mediated
Type 3
Also known as cell-mediated
Type 4
Wheal and flare skin (uticaria and hives)
What type of hypersensitivity?
1
hay fever, allergic asthma, hives and systemic anaphylaxis
What type of hypersensitivity?
1
2 major phases of type 1 hypersensitivity
sensitization and activation
Myasthenia gravis
What type of hypersensitivity?
2
Grave’s disease
What type of hypersensitivity?
2
Good pasture syndrome
What type of hypersensitivity?
2
Hashimoto’s disease
What type of hypersensitivity?
2
DM
What type of hypersensitivity?
2
Transfusion reactions, HDN, AHA, Cold agglutinins
What type of hypersensitivity?
2
SLE , RA
What type of hypersensitivity?
3
Arthus reaction and serum sickness
What type of hypersensitivity?
3
Contact dermatitis
What type of hypersensitivity?
4
Hypersensitivity pneumonitis
What type of hypersensitivity?
4
Pathogens in type IV
M. tuberculosis
M. leprae
P. carinii
Leishmania
Herpes
Preferred method in type I
skin prick
most common form of atopy or allergy
rhinitis
principal effector cells of immediate hypersensitivity
mast cells
gold standard in type IV-contact dermatitis
patch test
