immunopharacology

Question 1

cyclosporine, tacrolimus(FK506)

Answer 1

calcineurin inhibitors

Question 2

sirolimus, everolimus

Answer 2

proliferation-signal inhibitors(PSIs)

Question 3

azathioprine, mycophenolate mofetil

Answer 3

immunosuppressive antimetabolites

Question 4

methylprednisolone, prednisolone, prednisone

Answer 4

glucocorticoids

Question 5

ATG, basiliximab, daclizumab, OKT3(CD3에대한 항체)

Answer 5

immunosuppressive agents, antibody

Question 6

IL-2의 전사인자는?

Answer 6

NFAT

Question 7

NFAT를 활성화시키는 것은 ?

Answer 7

calcineurin을 통한 탈인산화

Question 8

tcell에 IL-2가 결합하면 ______을 통해 growth signal을 만든다.

Answer 8

mTOR

Question 9

_____는 FKBP와 결합하여 gof해서 calcineruin에 결합해 억제하여 ______를 불활성화시킨다.

Answer 9

tacrolimus, cyclosporin, NFAT

Question 10

cyclosporine that inhibitst he cytoplasmic phosphatase,________.

Answer 10

calcineurin

Question 11

cyclosoporine의 toxicity는(2가지)?

Answer 11

nephrotoxicity, hypertension

Question 12

cyclosporine is primarily metabolized by the________ enzyme.

Answer 12

CYP3A4

Question 13

what is CYP3A inhibition?

Answer 13

grapefruit, verapamil,fluconazole, ketoconazole, erythromycin(항생제), allopurinol, metoclopramide, methylprednisolone

Question 14

what is CYP3A inducor?

Answer 14

nafcillin, rifampin, pheobarbital, phenytoin등

Question 15

______binds to an intracellular protein, FK506-binding protein-12(FKEP-12).

Answer 15

tacrolimus

Question 16

sirolimus(rapamycin), everolimus

Answer 16

proliferation-signal inhibitos(PSIs)

Question 17

________ is a selective, noncompetitive, and reversible inhibitor of inosine monophosphate dehydrogenase(IMPDH)., an important enzyme in the denovo pathway of guanine nucleotide synthesis.

Answer 17

mycophenolate mofetil

Question 18

_______lyse and induce the redistribution of lymphocytes, casuing a rapid, transient decrease in peripheralblood lymphocyte counts. that complexes increase ____expression, thereby curtailing activation of Nf-kB, which increases apoptosis of activated cells. and key proinflammatory cytokines such as IL-1 and IL-6 are downregulated.

Answer 18

glucocorticoids, IkB

Question 19

humarnized antibody (90%이상) ‘s generic suffix is ___________.

Answer 19

-zumab

Question 20

_______ is a purified gamma globulin from the serum of rabbits immunized with human thymocytes.

Answer 20

ATG(anti thymocyte globulin)

Question 21

ATG의 toxicity 3가지는?

Answer 21

serum sickness and glomerulonephritis(사구체 신염), and anaphylaxis

Question 22

_________ is a monoclonal antibodies directed at the chain of CD3.

Answer 22

muromonab-CD3(OKT3)

Question 23

anti IL-2 R antibody 2가지는?

Answer 23

1. daclizumab 2. basiliximab(키메라 항체임)

Question 24

daclizumab과 basiliximab의 toxicity는?

Answer 24

okt3와 비교하면 cytokine releaase syndrome은 없지만 anaphylactic 은 여전히 발생한다.

Question 25

anti-TNF antibodies 3가지?

Answer 25

infliximab,etanercept, adalimumab

Question 26

_______ is mechanistically related to infliximab and contains ligand-binding portion of a human TNF-alpha R fused to the Fc portion of human IgG1.

Answer 26

etanercept

Question 27

APC의 LFA-3 리간드의 일부를 잘라 Tcell의 CD2R을 막는 약은?

Answer 27

alefacept

Question 28

1. t cell의 CTLA-4R을 막는 antibody는?
2. apc의 CD80/86을 막는 antibody는?

Answer 28

1. lpilimumab 2. abatacept

Question 29

암세포가 면역 회피 기작에 사용하는 PD-L1을 block하는 antibody는?

Answer 29

atezolizumab and avelumab

Question 30

면역 관문 억제약으로 노벨상을 받은 바이오 의약품은?

Answer 30

pembrolizumab, 키트루다, tcell의 PD-1을 block

Question 31

tcell의 PD-1을 block 하는 antibody 2가지?

Answer 31

pembrolizumab and nivolumab