GI pharmacology

Question 1

omeprazole

Answer 1

PPI

Question 2

_____, a prodrug, is converted to its active metaoblite via the CYP2C19 and CYP3A4

Answer 2

clopidogrel

Question 3

_____ decreases the metabolism of warfarin, diazepam, and phenytoin.

Answer 3

omerprazole

Question 4

______: inhibitors of gastric H+,K+ -ATPase(proton pump). 4가지

Answer 4

lansoprazole, omeprazole, raberprazole, pantoprazole

Question 5

omeprazole, lansoprazole, esomeprazole : _____ of CYP2C19.

Answer 5

inhibitor

Question 6

omeprazole, esomerprzole 과 rabeprazole,pantoprazole 간의 차이점

Answer 6

CYP2C19 inhibition 유무

Question 7

위산 분비 억제를 목적으로 쓰는 약 2가지는?

Answer 7

1) H2 blocker 2) PPI

Question 8

____: most potent inducer of acid secretion, produced by antral G cells.

Answer 8

gastrin,+) indirectly release of histamine by ECL cells, directly effect on parietal cells

Question 9

tegoprazan

Answer 9

PPI, potassium competitive acid blockers (P-CABs)

Question 10

H2 blocker의 clinical use는?

Answer 10

peptic ucler, refux oesophagitis(역류성 식도염)

Question 11

ranitidine 이슈는?

Answer 11

NDMA라는 발암물질이 함유되어있음

Question 12

H2 blocker의 작용은?

Answer 12

산 생성 감소, 산 분비 감소, 밤에 산 분비 감소

Question 13

cimetidine inhibit CYPs. drugs that are substrates for theses enzymes, example ________.

Answer 13

warfarin, phenytoin, phenobarbital, digitoxin

Question 14

______’s AE is a weak antiandrogenic agent. 구체적으로 gynecomastia and galactorrhea.

Answer 14

cimetidine

Question 15

amphetamine

Answer 15

appetite suppressant

Question 16

amphetamine increase ____ level in the neuronal terminal.
fenfluramine ______ R의 reuptake을 억제한다.
phenylpropanolamine ______R에 작용한다,

Answer 16

dopamine, 5-HT, alpha receptor

Question 17

sibutramine

Answer 17

appetite suppressant(5-HT과 NE의 기능에 작용)

Question 18

orlistat

Answer 18

GI lipase inhibitor, antiobesity

Question 19

liraglutide

Answer 19

GLP-1 agonist

Question 20

locaserin

Answer 20

5-HT2c agonist

Question 21

Phentermine과 같이 사용하여 살빼는 효과를 주는 항경련제는 무엇인가?

Answer 21

topiramate

Question 22

orlistat malabsorption of _______

Answer 22

vita ADEK

Question 23

orlistat irreversibly inhibit the enzymes, ________.

Answer 23

gastric and pancreatic lipases