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RUSVM Immunology > Immunology Test 1 Practice Questions Spring 2011 > Flashcards

Immunology Test 1 Practice Questions Spring 2011 Flashcards

1
Q

Alternative pathway complement proteins

A

C3/ Factor D

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2
Q

Bone marrow giant cell that gives rise to platelets

A

Megakaryocytes

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3
Q

alpha-1-antitrypsin inhibits this phagocyte enzyme, contributing to the reduction of tissue damage during the acute inflammatory response .

A

Elastase

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4
Q

A synonym for innate immunity

A

Non-specific immunity

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5
Q

Migrating Langerhans cell matures into dendritic cell in this region of the lymph node.

A

Paracortex

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6
Q

Antigen-specific lymphocytes develop and mature in these lymphatic organs.

A

Central lymphatic organs

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7
Q

Thymocytes originate from these bone marrow cells.

A

Lymphoid progenitor cells

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8
Q

The polymorphic amino acid residues that distinguish these MHC molecules are found in the amino terminal region of the two heterodimeric polypeptide chains.

A

Class 2 MHC molecules

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9
Q

The complement pathway may be activated by this bacterial structure.

A

Teichoic acid

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10
Q

T or F: CC chemokines recruit monocytes to sites of microbial invasion

A

T

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11
Q

T or F: Gram-positive bacteria are destroyed when complement membrane-attack com­plexes create pores in the bacterial cell membranes

A

F

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12
Q

T or F: Macrophages constitutively express class II MHC molecules and B7 proteins.

A

F

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13
Q

T or F: Both Ieukocytes and endothelial cells express selectin adhesion molecules

A

T

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14
Q

T or F: Formation of classical C3 convertase is abolished in animals with mutations in the C1q gene.

A

T

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15
Q

T or F: G-CSF cytokine promotes lymphocyte production.

A

F

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16
Q

T or F: Antigen cross-reaction describes the binding of antibody to an antigen that did not elicit production of that antibody

A

T

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17
Q

T or F: Leukocyte chemotaxis is a receptor-ligand mediated event.

A

T

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18
Q

T or F: The initial event in the acute inflammatory response is vascular permeability.

A

F

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19
Q

T or F: Animals with mutated recombination-activating genes cannot rearrange their TCR and BCR genes, hence cannot mount adaptive immune responses.

A

T

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20
Q

T or F: A decrease in MHC polymorphism within a species may predispose that species to multiple infectious agents.

A

T

21
Q

T or F: The bone marrow is the main source of acute-phase proteins.

A

F

22
Q

T or F: T lymphocytes are organized into follicles in the spleen.

A

F

23
Q

T or F: Complement component C1q binds to Fc region of antibodies.

A

T

24
Q

T or F: A cytokine acts only on cells that express receptors for it.

A

T

25
Q

T or F: The enzyme terminal deoxynucleotidyl transferase [TdT] promotes TCR diversity by catalyzing the insertion of P-nucleotides into the junctions between TCR variable region gene segments.

A

F

26
Q

T or F: The central arteriole delivers antigens and lymphocytes to the spleen.

A

T

27
Q

T or F: Protection against bystander lysis provided by S protein operates during activa­tion of both the classical and alternative complement pathways.

A

T

28
Q

Host defense of the skin against microbial invasion is the function of all of the fol­lowing except:

a. mechanical barrier provided by the stratum corneum.
b. acidic pH.
c. microglial cells.
d. epithelial shedding.

A

C. Microglial cells

29
Q

Which of the following is not a characteristic of both interleukin-1 and interleukin­-6?

a. Endogenous pyrogens.
b. Increased adhesiveness of endothelium.
c. Induction of acute-phase proteins.
d. None of the above.

A

b. Increased adhesiveness of endothelium.

30
Q

This complement fragment promotes the acute inflammatory response by in­ducing degranulation of mast cells.

a. C3b
b. C3a
c. Properdin
d. C2a

A

b. C3a

31
Q

Regarding TCRs, which of the following statements is inaccurate?

a. TCRs are clonotypic.
b. TCRs are heterodimeric cell membrane proteins.
c. TCRs are subject to MHC restriction.
d. TCR gene rearrangements begin in Pre-T cells and continue in mature T cells.

A

D

32
Q

Acute-phase proteins include all of the following except:

a. complement proteins.
b. iron-binding proteins.
c. lipopolysaccharide-binding proteins.
d. interleukin-1.

A

D. IL-1 is not an acute phase protein

33
Q

Regarding neutrophils, which of the following statements is incorrect?

a. Neutrophils are capable of both random and chemotactic movements.
b. The half-life of tissue neutrophils is 8 days.
c. Neutrophils are polymorphonuclear granulocytes.
d. Neutrophils are activated and recruited by CXCL8 chemokine.

A

B in incorrect

34
Q

Which of the following pairs is mismatched?

a. CD28: B7 proteins.
b. Viroceptor: cytokine receptor antagonist.
c. CD35: lgG.
d. PECAM-1: PECAM-1.

A

c. CD35: lgG is mismatched

35
Q

Regarding complement activation, which of the following statements is least ac­curate?

a. Factor p [properdin] must dissociate from the alternative C5 convertase prior to the binding and subsequent cleavage of C5.
b. C1s cleaves C2 only after C2 has undergone substrate modulation.
c. C5b67 is a hydrophobic trimolecular complex.
d. Activation of the alternative pathway is antibody-independent.

A

A is inaccurate

36
Q

The role of macrophages in the thymus include all of the following except

a. destruction of microorganisms.
b. secretion of cytokines.
c. engulfment of apoptotic thymocytes.
d. activation of thymocytes to produce effector and memory cells

A

D

37
Q

Regarding antigens and haptens, which of the following statements is not accurate?

a. Glycoproteins are the best antigens
b. Haptens can be recognized by antibody.
c. Alloantigen describes a substance that may be detectable by members of the same species.
d. Haptens induce immune responses when coupled to carrier molecules.

A

A. Glycoproteins are NOT the best antigens

38
Q

Invariant T cell membrane molecules include all of the following except

a. CD28.
b. CD3.
c. CD4 .
d. TCR

A

D

39
Q

Proenzyme complement components include all of the following except

a. factor B
b. C3
c. C8
d. C4

A

C

40
Q

Each of the following is an important source of cytokines except

a. activated endothelial cells.
b. activated macrophages.
c. T lymphocytes.
d. platelets.

A

D

41
Q

Which lymphatic organ does not involute?

a. Bursa of Fabricius
b. Spleen
c. Ileal Peyer’s patch
d. Thymus

A

B. Spleen does not involute

42
Q

The following regulatory proteins are paired with their functions. Which pair is mismatched?

a. Factor H: binds to C3b.
b. Anaphylatoxin inactivator: inactivation of C5b67 complex.
c. Decay: accelerating factor-dissociation of C3 convertases.
d. CD59: inhibition of MAC formation.

A

B

43
Q

Regarding MHC genes and molecules, which of the following statements is inac­curate?

a. The invariant chain [Ii] associates with class II MHC molecule in the endosome.
b. Some MHC genes code for complement proteins.
c. MHC genes are codominantly expressed.
d. Mutation in the beta-2-microglobulin gene will preclude the expression of class I MHC molecule.

A

A

44
Q 
The following complement fragments facilitate the phagocytosis of bacteria and 
other microbes except 
a. C5b. 
b. iC3b. 
c. C4b. 
d. C3b.
A

A

45
Q

Antimicrobial products of neutrophils include all of the following except

a. H202
b. lysozyme.
c. nitric oxide.
d. hypochlorous acid.

A

C

46
Q

Pattern recognition receptors are expressed by each of the following cells except

a. macrophages.
b. T lymphocytes.
c. neutrophils.
d. none of the above.

A

B

47
Q

Chemotactic agents that stimulate the migration of leukocytes include all of the following except

a. C5a.
b. CXCL8.
c. Bb.
d. N-formylated peptides.

A

C. Bb

48
Q

The most important requirement for antigenicity of a substance is:

a. Chemical complexity
b. Molecular weight
c. Foreignness
d. Degradability

A

C

49
Q

Which pair is mismatched?

a. Cytokine: endocrine function
b. TCR beta: VJC beta genes
c. Lipid vasoactive mediator: platelet-activating factor
d. Thymic epithelial cell: thymocyte selection

A

B

RUSVM Immunology (7 decks)

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