Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

RUSVM Immunology > Immunology Test 1 Practice Questions Fall 2012 > Flashcards

Immunology Test 1 Practice Questions Fall 2012 Flashcards

1
Q

The secreted form of interleukin-1 which mediate its endocrine function.

A

IL-1b

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

This organ synthesizes and secretes most of the plasma proteins that play significant roles in host pathogens against invading pathogens.

A

Liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Chemical mediator of the pain that is a major feature of acute inflammation.

A

Bradykinin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Iron promotes microbial growth. This host protein binds free iron, leading to microbial iron deficiency and impaired growth.

A

Lactoferrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Properdin (factor P) is a positive regulator of this complement activation pathway.

A

Alternative complement pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

The non-MHC encoded protein B2 microglobulin is required for the assembling and stable expression of this MHC molecules.

A

MHC-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Neutrophil activation by CXCL8 leads to conformational rearrangement and increased adhesiveness of this neutrophil cell adhesion molecule.

A

Integrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Lymphoid follicles are normally found in this lymph node region.

A

Cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Also called cross-reacting antigen.

A

Heterophile antigen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

This professional phagocyte is also a major source of cytokines that promote the inflammatory response.

A

Macrophage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

T or F: 1. S protein-C5b67 complex cannot penetrate target cell or host cell membrane.

A

T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

T or F: 2. Specialized antigen-presenting cells capture microbial antigens, process them and display antigenic peptides for recognition by T lymphocyctes.

A

T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

T or F: 3. Only a cell expressing the appropriate receptor can respond to a particular cytokine.

A

T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

T or F: 4. The edema of acute inflammation involves the exudation of protein-rich fluid primarily only through capillaries.

A

F

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

T or F: 5. Very few microorganisms are able to penetrate the intact skin.

A

T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

T or F: 6. In secondary lymphoid organs, lymphocytes are activated to participate in adaptive immune responses.

A

T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

T or F: 7. The term hapten is used interchangeably with the term antigen.

A

F

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

T or F: 8. Phagocytic cells move toward microorganisms by cytoplasmic streaming in response to chemotactic agents that are generated in high concentrations at sites of microbial invasion.

A

T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

T or F: 9. The classical complement pathway can be activated by one molecule of pentameric IgM bound to the bacterial cell or by one molecule of IgG bound to the bacterial cells.

A

F

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

T or F: 10. High endothelial venule [HEV] is a specialized section of the postcapillary venule where diapedesis of lymphocytes from the blood into the lymph node occurs.

A

T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

T or F: 11. Different groups of microorganisms express different pathogen-associated molecular patterns [PAMPS].

A

T

22
Q

T or F: Cytokines are secreted by multiple immune and nonimmune cells.

A

T

23
Q

T or F: 13. In general, because a polysaccharide antigen expresses diverse epitopes, the most effective host immune response is produced to polysaccharide antigen.

A

F

24
Q

T or F: A complement protein always circulates in the blood in an active state.

A

T

25
Q

T or F: 15. Class I MHC molecule and class II MHC molecule bind peptides that are derived from proteins processed in different cellular compartments.

A

T

26
Q

T or F: Activated macrophages are major sources of interleukin-6 and tumor necrosis factor-alpha.

A

T

27
Q

T or F: 17. High cell membrane level of sialic acid promotes the rapid inactivation of cell membrane bound C3b by soluble factors H and I.

A

T

28
Q

T or F: An individual or animal expresses equal numbers of class I and class II MHC molecules.

A

F

29
Q

The most important complement-derived opsonin.

a. iC3b
b. C4b
c. C3b
d. C5b

A

c

30
Q
  1. Which neutrophil product is not involved in microbial inactivation?
    a. H2O2
    b. Lysozyme
    c. Collagenase
    d. Hypochlorous acid
A

c

31
Q
  1. Which of the following statements about interleukin-1 is incorrect?
    a. It is produced principally by activated macrophages.
    b. It promotes endothelial cell adhesiveness by inducing the expression of adhesion molecules.
    c. It promotes the systemic inflammatory response syndrome that is a principal feature of the acute inflammatory response.
    d. Interleukin-1alpha and interleukin-1beta mediate different biologic functions because each binds to a different receptor on the target cell.
A

d

32
Q
  1. Which cells is not derived from myeloid progenitor stem cell?
    a. Eosinophil
    b. Natural killer cells
    c. Basophil
    d. Neutrophil
A

b

33
Q
  1. Which of the following complement fragments attaches to the Fc region of IgM?
    a. C1qrs
    b. C2b
    c. C4b2b
    d. C5b
A

a

34
Q
  1. Which of the following pairs is mismatched?
    a. Megakaryocyte —platelets
    b. Innate immunity —memory
    c. Antigenic determinant —epitope
    d. Integrin cell adhesion molecule —Ig superfamily cell adhesion molecule
A

b

35
Q
  1. Regarding the thymus, which of the following statements is least accurate?
    a. It is the site of T cell development and differentiation in mammals and birds.
    b. It is a lymphoepithelial organ.
    c. Apoptotic thymocytes are cleared by resident macrophages.
    d. Thymocyte development into mature T cell occurs predominantly in the medullary region.
A

d. Thymocyte development into mature T cell occurs predominantly in the medullary region. – naïve T-cell

36
Q
  1. A lysosome
    a. Is a cytoplasmic organelle containing digestive enzymes
    b. Hydrolyzes bacterial peptidoglycan
    c. Destroys gram-positive bacterial cell walls
    d. Is an enzyme.
A

a

37
Q
  1. Certain proteins in the plasma, collectively called acute-phase proteins, may increase in concentration during the early phase of the inflammatory reaction. Such proteins include all of the following except
    a. Bradykinin
    b. Lipopolysaccharide-binding protein
    c. C-reactive protein
    d. Iron-binding protein
A

a

38
Q
  1. The rise in temperature that causes a fever is due to the hypothalamus responding to
    a. C5a
    b. CXCL8
    c. Tumor necrosis factor-alpha
    d. IL-1ra
A

c

39
Q
  1. Each complement component is paired with a function. Which paid is mismatched?
    a. Bb —activation and immobilization of macrophage
    b. C2a — mast cell degranulation
    c. C5b6789 — cell lysis
    d. C1s — cleavage of C4 into C4a and C4b
A

b. C2a — mast cell degranulation – not C2a; C3a, C4a, C5a

40
Q
  1. Which of the following statements describes neutrophils?
    a. They are long-lived cells.
    b. They are not terminally differentiated cells
    c. They possess primary and secondary granules
    d. They circulate in the blood for 20-36 hours before migrating into tissues
A

c

41
Q
  1. Which complement fragment promotes the cleavage of C5 into C5a and C5b by C3bBb?
    a. C2b
    b. C3b
    c. C3a
    d. C4b
A

b

42
Q
  1. Regarding antigens, which of the statements below is least accurate?
    a. May be microbial or nonmicrobial in nature
    b. A chemically complex substance is more antigenic
    c. An antigen can act as a carrier for a hapten molecule
    d. Antigens entering the body through the skin are carried by afferent lymphatic vessels to the spleen
A

d

43
Q
  1. Cytokines and polypeptide hormones that regulate T cell development in the thymus include all of the following except
    a. Interleukin-7
    b. Thymopoietin
    c. Tumor necrosis factor
    d. Thymic humoral factor
A

c

44
Q
  1. Nonspecific factors that provide resistance against invading microbes include each of the following except
    a. Epithelial barriers
    b. Tears
    c. Antibody
    d. Stomach acid
A

c

45
Q
  1. Which leukocyte is not found in avian blood?
    a. Neutrophil
    b. Eosinophil
    c. Lymphocyte
    d. Monocyte
A

a

46
Q
  1. Which of the following is the major function of the lymphoid system?
    a. Inflammation
    b. Adaptive immunity
    c. Phagocytosis
    d. Innate immunity
A

b

47
Q
  1. Regarding the major histocompatibility complex, which of the following statements is incorrect?
    a. MHC molecules were originally discovered because of their major role in allograft acceptance or rejection
    b. Host cells that do not express MHC molecules include erythrocytes and neurons
    c. MHC molecules are genetic markers of biological individuality
    d. In mammals, MHC genes are found on the same chromosome.
A

d

48
Q
  1. Each cytokine is matched with a characteristic or function. Which pair is mismatched?
    a. Interluekin-6 — production of neutrophils and platelets
    b. CXCL8 — recruitment and activation of macrophages
    c. TNF-alpha —cachectin
    d. Interleukin-3 —hematopoiesis
A

b. CXCL8 — recruitment and activation of macrophages – leukocytes, not macrophages

49
Q
  1. Which complement protein does not belong with the others?
    a. Properdin [factor P]
    b. C3bBb
    c. C6
    d. Factor D
A

c

50
Q
  1. During the inflammatory response, the following chemical substances mediate the dilation and increased permeability of the vessels constituting the microvasculature except
    a. Histamine
    b. Nitric oxide
    c. C5b
    d. Prostaglandin.
A

c

RUSVM Immunology (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions