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RUSVM Immunology > Immunology Test 1 Practice Questions Spring 2010 > Flashcards

Immunology Test 1 Practice Questions Spring 2010 Flashcards

1
Q

What is an antigen-specific professional antigen-presenting cell?

A

B lymphocyte

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2
Q

What is a heterodimeric cell adhesion molecule that mediates the recruitment of leukocytes to inflamed tissue?

A

Integrin

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3
Q

What is a bone marrow progenitor cell that gives rise to granulocytic leukocytes?

A

Myeloid progenitor cell

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4
Q

Antigenic peptide consisting of 20-25 amino acids is complexed with this MHC molecule.

A

Class 2 MHC molecule

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5
Q

Activation of this cell by anaphylatoxins, leads to the release of chemical media­tors such as prostaglandins, leukotrienes, and histamine.

A

Basophils

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6
Q

A molecule that is antigenic in genetically different members of the same species.

A

Alloantigen

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7
Q

This highly conserved amino acid is used to classify chemokines into sub­families.

A

Cysteine

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8
Q

Initiators of the alternative complement pathway include this bacterial structure.

A

Teichoic acid

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9
Q

Adaptive immune response to antigens breaching mucosal epithelia, take place in this lymphatic organ

A

Lymph node

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10
Q

A cardinal sign of acute inflammation.

A

Swelling

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11
Q

Ileal Peyer’s patch functions as a primary lymphatic organ in these domestic animals.

A

Pigs and dogs

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12
Q

Synonyms for innate immunity include:

A

Native and natural

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13
Q

Classical pathway complement proteins include:

A

C3b and C4b

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14
Q

Host cell enzymes that break down H2O2 include:

A

Catalase and glutathione peroxidase

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15
Q

Periarteriolar lymphatic sheath is part of the inner region of this lymphatic organ.

A

Spleen

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16
Q

Giant cells and epithelioid cells that characterize chronic inflammations arise from this cell.

A

Macrophage

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17
Q

T or F: The peptide-binding cleft of class I MHC molecule is formed by separate alpha and beta and protein chains.

A

F: alpha chain and B2m

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18
Q

T or F: A characteristic of peripheral lymphatic organs is that they do not regress following sexual maturity.

A

T

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19
Q

T or F: Polysaccharide antigens elicit the best immune responses in hosts.

A

F

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20
Q

T or F: Cytokines regulate both innate and adaptive immune responses.

A

T

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21
Q

T or F: The vascular changes that characterize acute inflammation, occur only in the arterioles, capillaries, and venules.

A

T

22
Q

T or F: T-cell development occurs mostly in the thymic medulla.

A

F

23
Q

T or F: A hapten cannot illicit an immune response unless it is bound to a carrier substance.

A

T

24
Q

T or F: CC chemokines facilitate the recruitment of neutrophils to inflammatory tissue.

A

F- macrophages

25
Q

T or F: Thymocytes that undergo negative selection during development in the thymus die by cell necrosis.

A

F

26
Q

T or F: The liver is a major source of complement proteins and iron binding proteins.

A

T

27
Q

T or F: Heterophile antigens account for some false-positive diagnosis.

A

T

28
Q

T or F: Only adaptive immune responses demonstrate immunologic memory.

A

T

29
Q

T or F: Cytokines are constitutively produced by most cells.

A

F

30
Q

T or F: The classical complement pathway is activated when complement protein C1 encounters free IgG molecule in the circulation.

A

F- IgG must be bound

31
Q

T or F: Under normal conditions, most of the cellular blood elements are found in the central pool

A

T

32
Q

By activating and immobilizing macrophages, this complement fragment me­diates the retention of macrophages at sites of bacterial invasion.

A

Bb

33
Q

Each of the following is a description of innate immunity except:
A. rapid response
B. involvement of pathogen-associated molecular patterns
C. fever
D. It is a major function of the lymphatic system

A

D describes adaptive immunity

34
Q 
Nonantibody factors in plasma that act to opsonize pathogens include all of the following except:
A. C4a
B. C3b
C. iC3b
D. C-reactive protein
A

A. C4a

35
Q

Which cytokine promotes T cell and B cell development in primary lymphatic organs?

A

IL-7

36
Q 
Microbicidal reactive oxygen species generated within neutrophil phagolysosome include each of the following except:
A. hydrogen peroxide
B. hypochlorous acid 
C. nitric oxide
D. superoxide anion
A

C. nitric oxide- macrophages

37
Q

A function of mature dendritic cell is the:

A

activation of naive antigen-specific T-cells

38
Q

Regarding a lymph node, which of the following statements is incorrect?
A. A lymph node has both afferent and efferent lymph vessels.
B. Depletion of cells in the lymph node cortex is indicative of T cell deficiency.
C. Circulating lymphocytes enter the node via high endothelial venules.
D. It is a peripheral lymphatic organ.

A

B is incorrect

39
Q

Each complement protein is paired with a function. Which pair is mismatched?
A. Properdin [factor P]-Cleavage of C4 protein
B. Factor-Inactivation of C3b
C. CD59-Prevention of host cell lysis
D. C5a-Recruitment of leukocytes

A

A is mismatched. Properdin stabilizes C3bBb

40
Q

MHC class I molecules are important for which of the following?
A. Binding to CD4 molecules on T cells
B. Binding to CD8 molecules on T cells
C. Presenting antigenic peptides to macrophages
D. Binding to the invariant chain

A

B. Binding to CD8 molecules on T cells

41
Q

S protein regulates the complement system to prevent complement-mediated lysis of cells. This involves:

A

blocking the binding of C5b67 to cell surfaces

42
Q

Regarding IL-6, which of the following statements is least accurate?
A. A major source of IL-6 is the activated macrophage
B. Initiate acute-phase responses
C. Has endogenous pyrogen property
D. At high concentration, IL-6 is associated with toxic shock syndrome

A

D is not true, TNF-a is associated with TSS

43
Q

Regarding the chemokine CXCL8, which of the following statements is least accurate?

a. It is a low-molecular-weight protein.
b. It is also referred to as IL-8.
c. It facilitates the recruitment of eosinophils and macrophages to sites of in­flammation.
d. Activates neutrophils, upregulating the expression and rearrangement of cell surface integrins.

A

C is not true

44
Q

Which of the following statements describes a neutrophil?
A. A hallmark of neutrophil deficiency is recurrent bacterial infections.
B. Neutrophils do not respond to chemotactic stimuli.
C. Neutrophils recirculate between peripheral tissues and circulatory system.
D. Resident neutrophils provide the first line of cellular defense in the host.

A

D is not true. Resident macrophages provide the first line of cellular defense in the host

45
Q

Which of the following pairs of cell adhesion molecules mediating leukocyte extravasation do not interact with each other?

a. PECAM-1 and PECAM-1
b. VLA-4 and VCAM-1
c. ICAM-1 and L-selectin
d. CD11aCD18 and ICAM-2

A

C. ICAM-1 and L-selectin do not interact

46
Q

Regarding macrophages, which of the statements below is incorrect?

a. Process and present antigens to T cells.
b. Produce cytokines.
c. Secrete complement proteins.
d. Cytoplasmic contents include primary and secondary Iysosomes

A

D is incorrect

47
Q 
Which of the following antibacterial substances present in the phagolysome, 
cannot kill the bacterial cell? 
a. Collagenase
b. Lysozyme
c. Defensin
d. Bactericidal-permeability protein
A

a. Collagenase cannot kill the bacterial cell

48
Q

Complement activation includes the cleavage of a number of complement pro­teins to yield two fragments. Which complement protein is not cleaved?

A

Factor D

49
Q

Chemical mediators of acute inflammation include all of the following except:

a. bradykinin.
b. histamine.
c. C3b.
d. lipopolysaccharide.

A

Chemical mediators of acute inflammation do not include C3b (c).

50
Q

Which of the following is incorrectly paired?

a. Antigenic determinant – Epitope
b. HLA-DM – CLIP removal from peptide cleft
c. Activated endothelium – Expression of cell adhesion molecules
d. Naive T-cell – Recirculation to inflamed tissue

A

d. is incorrect. It should be EFFECTOR T-cell – Recirculation to inflamed tissue

RUSVM Immunology (7 decks)

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