immunology hypersensitivity reactions Flashcards
what type of immune response is hypersensitivity
adaptive immune response
2 stages of hypersensitivity
sensitization
effector
type 1 hypersensitivity
1-30 min
IgE mediated
ex. peanuts, schistosomes
type 2 hypersensitivity
5-8 hrs
IgM IgG mediated
occurs after second exposure
ex. immune hemolytic anemias
type 3 hypersensitivity
4-6 hours
immune complex mediated
ex. post strep glomerulonephritis
type 4 Hypersensitivity
24-72 hours
T-cell mediated
ex. poison ivy, MS
types of type 1 hypersensitivity reactions
allergy
atopy
anaphylaxis
anaphylactoid
what is an allergy
hypersensitivity reaction to exogenous substances
what is an atopy
hypersensitivity reaction mediated by IgE- systemic or local
Anaphylaxis is what
most extreme form of immediate hypersensitivity
what is anaphylactoid
non-immune mediated immediate hypersensitivity reaction: cold induced asthma
what is desensitization
pushed toward Th1 response to increase Tregs
examples of type 2 hypersensitivity
good pasture syndrome
hemolytic anemia
erythroblastosis fettles
graves disease
Myasthenia gravis
transfusion reactions
pemphigus vulgaris
what is hemolytic anemia
ag-ab binds surface of RBC and phagocytoses it
what is erythroblastosis fetalis
antigenic difference between mother and fetus
