immunology hypersensitivity reactions Flashcards

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1
Q

what type of immune response is hypersensitivity

A

adaptive immune response

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2
Q

2 stages of hypersensitivity

A

sensitization
effector

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3
Q

type 1 hypersensitivity

A

1-30 min
IgE mediated
ex. peanuts, schistosomes

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4
Q

type 2 hypersensitivity

A

5-8 hrs
IgM IgG mediated
occurs after second exposure
ex. immune hemolytic anemias

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5
Q

type 3 hypersensitivity

A

4-6 hours
immune complex mediated
ex. post strep glomerulonephritis

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6
Q

type 4 Hypersensitivity

A

24-72 hours
T-cell mediated
ex. poison ivy, MS

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7
Q

types of type 1 hypersensitivity reactions

A

allergy
atopy
anaphylaxis
anaphylactoid

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8
Q

what is an allergy

A

hypersensitivity reaction to exogenous substances

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9
Q

what is an atopy

A

hypersensitivity reaction mediated by IgE- systemic or local

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10
Q

Anaphylaxis is what

A

most extreme form of immediate hypersensitivity

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11
Q

what is anaphylactoid

A

non-immune mediated immediate hypersensitivity reaction: cold induced asthma

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12
Q

what is desensitization

A

pushed toward Th1 response to increase Tregs

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13
Q

examples of type 2 hypersensitivity

A

good pasture syndrome
hemolytic anemia
erythroblastosis fettles
graves disease
Myasthenia gravis
transfusion reactions
pemphigus vulgaris

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14
Q

what is hemolytic anemia

A

ag-ab binds surface of RBC and phagocytoses it

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15
Q

what is erythroblastosis fetalis

A

antigenic difference between mother and fetus

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16
Q

type 3 hypersensitivity reactions defect in what

A

immune complex clearance
defect in complement classical cascade
- accumulation in vessels
- vasculitis

17
Q

examples of type 3 hypersensitivity

A

polyertiertis nodosa
serum sickness
SLE

18
Q

type 4 hypersensitivity examples

A

TB granuloma
diabetes
crohns