Immunology Flashcards
intrinsic epithelial barriers to infection
skin
mucous membrane
primary lymphoid tissue
anatomical sites where leukocytes are produced
bone marrow
thymus
secondary lymphoid tissue
where lymphocytes are associated during adaptive immune responses
cellular components of immune system
develop from haematopoietic stem cells in bone marrow blood natural killer cells mast cells, eosinophil, basophil monocytes, macrophages, neutrophils dendrite cells t cells and b cells
humoral components of immune system
antigens and antibodies
complement system proteins
cytokines
opsonisation
enhances phagocytosis
soluble factors
coating of pathogens
C3b CRP
neutrophil killing mechanism
phagocytosis
degranulation
neutrophil extracellular traps
antigen
is any substance which can cause an adaptive immune response
antibodies
are proteins that bind to one specific antigen
complex of 4 polypeptide chains
each antibody has a unique variable region v
y shaped, flexible
IgM
first Ig type produced during humoral response
agglutination
clumping together of particles caused by antibody binding to antigens on different cells
IgG
dominates in second exposure to antigen
crosses the placenta
monomeric
most effective
IgD
only on b cell surface membrane
IgE
allergy
IgA
second most abundant
in breast milk
monomeric form in serum
dimetric form in secretory fluids
