immunology

Question 1

what does SPUR stand for ?

Answer 1

S - serious infections = unresponsive to oral antibiotics
P - persistent infections = early structural damage, chronic infections
U - unusual infections = unusual organisms and sites
R - recurrent infections = two major or one major and one minor recurrent minor infections in one years

Question 2

what is a secondary immunodeficiency disorder?

Answer 2

common, often subtle, often includes more than one component of immune system

Question 3

what conditions are associated with secondary immune deficiency?

Answer 3

• ageing, measles, anti-cancer agents, leukaemia, malnutritions

Question 4

what is a primary immunodeficiency disorder (PIDs) - resp ?

Answer 4

• resp are main ones
• pulmonary complications cause significant morbidity and mortality in patients with PIDs
• early diagnosis and appropriate treatment can prevent or at least slow the development of resp complications

Question 5

what are the upper resp complications of PIDs?

Answer 5

• sinusitis
• otitis media
• laryngeal angioedema

Question 6

what are the lower resp complications of PIDs?

Answer 6

• malignancies
• interstitial lung diseases
• pneumonia
• bronchitis, bronchiectasis

Question 7

what is the most frequent associated PID of sinusitis and otitis media?

Answer 7

• primary antibody deficience (PAD)

- selective IgA deficiency

Question 8

what should be considered in patients with laryngeal angioedema?

Answer 8

• complement system disorders

Question 9

what is the most frequent manifestations of many PIDs?

Answer 9

pneumonia

Question 10

what happens as your neutrophils count increases?

Answer 10

your risk of disease decreases