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Path Past > Immunology > Flashcards

Immunology Flashcards

1
Q

How to monitor SLE

A

C3 and C4

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2
Q

HIV Test

A

Western Blot

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3
Q

Anti-SCL70

A

Systemic Sclerosis (TGF B linked to prognosis somehow)

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4
Q

Anti-Sm

A

SLE

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5
Q

HIV Monitoring

A

CD4 levels and viral load

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6
Q

Anti-cardiolipin

A

Antiphospholipied Syndrome

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7
Q

Nose bleeds and haematuria

A

Wegener’s Granulomatosis c-ANCA

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8
Q

Pruritus in a woman (PBC) What antibody

A

Anti-mitochondrial antibody

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9
Q

Wegeners patient already getting prednisolone and needs another drug

A

Cyclophosphamide

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10
Q

Rheumatoid arthritis DMARD

A

Tocilizumab

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11
Q

Psoriasis or Psoriatc Arthritis DMARD

A

Ustekinumab

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12
Q

Temporal Arteritis (Raised ESR) drug

A

Prednisolone

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13
Q

Osteoporosis DMARD

A

Denosumab

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14
Q

CGD Management

A

Infliximab

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15
Q

Worsening Crohn’s patient already taking azathioprine

A

Methotrexate

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16
Q

Ankylosing Spondylitis

A

NSAID. If uncontrolled, Infliximab

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17
Q

Common variable immunodeficiency management

A

Pooled Ig

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18
Q

C1 esterase inhibitor deficiency patient can talk

A

IV C1 inhibitior

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19
Q

Rash after eating in a patient

A

oral antihistamines (h1)

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20
Q

Anaphylaxis

A

IM Adrenaline

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21
Q

Urticaria

A

H1 anatgonist

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22
Q

Exercise induced urticaria

A

H1 antagonist

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23
Q

Acute angiodema

A

IM Adrenaline

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24
Q

Hayfever management

A

Allergy desensitisation

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25
Q

Cytokine responsible for promoting antibody synthesis

A

IL4

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26
Q

Main cellular source of histamine

A

Mast Cell

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27
Q

How to measure mast cell degranulation

A

Serum tryptase levels

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28
Q

Chemokine responsible for eosinophil growth

A

IL5

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29
Q

First cell for initial encounter with allergen

A

Macrophage

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30
Q

IL4 stimulates

A

B cells

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31
Q

First cytokine released in contact dermatitis

A

IL-12

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32
Q

Carcinoid syndrome?

A

Enterochromaffin cell tumour producing serotonin. Causing bronchoconstriction, flushing, diarrhoea. Give Octreotide

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33
Q

MEFV gene is mutated in…

A

Familial Mediterranean Fever

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34
Q

gp120 binds to

A

CCR5 or CXCR4

35
Q

gp41

A

Allows penetration

36
Q

Non neutralising antibodies are formed against

A

p24

37
Q

Protease inhibitor

A

Ritonavir

38
Q

Neutralising antibodies

A

anti-gp120 anti-gp41

39
Q

CCR7

A

chemokine receptor on t helper cells

40
Q

Target for HIV medication

A

Protease inhibitor

41
Q

A 6-month old boy with severe failure to thrive and recurrent infections etc… his T cells were undetectable and B cells were normal.

A

SCID

42
Q

Someone with three previous episodes of meningococcal meningitis

A

C7 deficiency

43
Q

Someone with normal CD8 levels but absent CD4

A

Bare lymphocyte Syndrome

44
Q

Low IgA, IgG but raised IgM

A

CD40L deficiency/Hyper IgM syndrome

45
Q

Kid with immune def that has improved with age but now mum is concerned about delayed speaking and language

A

Di George Syndrome

46
Q

Patient gets recurrent infections with negative NBT and dihdrorrhadamine tests

A

Chronic Granulomatous Disease

47
Q

Atypical granulomatous infection in previously healthy patient. Recurrent salmonella and mycobacteria infections

A

IFN-gamma receptor deficiency or IL-12 deficiency

48
Q

Patient treated for RA getting mycobacterial infections

A

Iatrogenic due to infliximab

49
Q

Vaccine to avoid in immunodeficiency

A

Yellow Fever

50
Q

Asplenic patients vaccine every 5 years

A

Pneumovax

51
Q

Avoid routine vaccine in immunodeficient patient

A

MMR

52
Q

Which one against viral haemagglutinin

A

Influenza

53
Q

Vaccine that you shouldn’t give to someone on infliximab if theyre travelling to Africa

A

Typhoid

54
Q

Vaccine sometimes used post exposure as prophylaxis

A

Rabies

55
Q

Vaccine which changes every year due to change in structure of pathogen

A

Influenza

56
Q

Name of vaccine that eradicated smallpox

A

Vaccinia

57
Q

What vaccine don’t you give to someone with Ank Spond on Infliximab

A

Yellow fever

58
Q

What vaccine do you give to 12-13yr old girls

A

HPV

59
Q

Graves Disease Immune Type

A

II

60
Q

Serum Sickness Immune Type

A

III

61
Q

Atopic Eczema

A

I

62
Q

CD40L is associated with

A

Hyper IgM syndrome

63
Q

Anti-Ro Anti-La

A

Sjogrens

64
Q

Anti-ttg

A

Coeliac

65
Q

CREST

A

anti-centromere

66
Q

SLE

A

anti-dsDNA

67
Q

Pernicious anaemia

A

Anti-parietal cell

68
Q

What is most important in HLA typing?

A

DR>B>A

69
Q

Antibodies against endothelial cells in transplant rejection

A

Acute vascular

70
Q

T-cells mediating rejection

A

Acute cellular

71
Q

Super fast rejection straight after insertion

A

HLA Typing or ABO mismatch

72
Q

Rejection years after

A

Immune and non immune

73
Q

Donor cells attack host resulting in hyperacute rejection

A

GVHD

74
Q

Immune Modulator Anti-CD25

A

Basiliximab

75
Q

Immune Modulator IL6 R

A

Tocilizumab

76
Q

Immune Modulator IL12/23

A

Ustekinumab

77
Q

Immune Modulator CTLA4

A

Abatacept

78
Q

Immune Modulator CD2

A

Alemtuzumab

79
Q

Immune Modulator TNF alpha

A

Infliximab

80
Q

Immune Modulator Anti C5

A

Ecalizumab

81
Q

Immune Modulator VCAM 1

A

Natalizumab

82
Q

APECED mutation

A

AIRE

83
Q

IPEX mutation

A

FOXP3

84
Q

APLS mutation

A

Fas

Path Past (8 decks)

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