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BPT Written > Immunology > Flashcards

Immunology Flashcards

1
Q

T helper type 1 cell (Th1) inducer cytokine

A

IL-12

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2
Q

T helper type 2 cell (Th2) inducer cytokine

A

IL-4

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3
Q

T helper 17 cell (Th17) inducer cytokines

A

IL-1
IL-6
IL-21
IL-23

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4
Q

Regulatory T cell (Treg) inducer cytokines

A

IL-2

TGF-β

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5
Q

T helper type 1 cell (Th1) cytokines produced

A

IFN-γ

TNF-α

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6
Q

T helper type 2 cell (Th2) cytokines produced

A

IL-4
IL-5
IL-6
IL-13

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7
Q

T helper type 17 cell (Th17) cytokines produced

A

IL-17

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8
Q

Regulatory T cell (Treg) cytokines produced

A

IL-10

TGF-β

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9
Q

Type I allergic reaction

A

IgE mediated, immediate-type hypersensitivity.

  • IgE mediated activation of mast cells & basophils, releasing vasoactive substances
  • Anaphylaxis, angioedema, bronchospasm, urticaria, hypotension
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10
Q

Type II allergic reaction

A

Antibody-dependent cytotoxicity.

  • Antigen associated with cell binds to antibody, leading to cell/tissue injury
  • Haemolytic anaemia, thrombocytopenia, neutropenia
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11
Q

Type III allergic reaction

A

Immune complex disease.

  • Deposition of antigen-antibody complexes in vessels/tissue, complement activation, neutrophil recruitment
  • Serum sickness, arthus reaction
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12
Q

Type IV allergic reaction

A

Cell-mediated or delayed hypersensitivity.

  • Antigen exposure activates T cells, mediating tissue injury, subsequent cell recruitment
  • Contact dermatitis, mobilliform reactions, exfoliative dermatoses, AGEP, DRESS, interstitial nephritis, drug-induced hepatitis
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13
Q

Serology - type I hereditary angioedema (HAE)

A

Low C4
Low C1INH protein level
Low C1INH functional level
Normal C1q

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14
Q

Serology - type II hereditary angioedema (HAE)

A

Low C4
Normal C1INH protein level
Low C1INH functional level
Normal C1q

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15
Q

Serology - acquired C1INH deficiency

A

Low C4
Low C1INH protein level
Low C1INH functional level
Low C1q

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16
Q

Serology - X-linked agammaglobulinaemia (XLA)

A

Normal T cells

Low / absent B cells

17
Q

Serology - hyperimmunoglobulin M syndrome (HIGM)

A

Normal / High IgM
Low IgG
Low IgA
Low IgE

18
Q

Serology - common variable immunodeficiency (CVID)

A

Low IgG

Low IgM and/or IgA

19
Q

Serology - severe combined immunodeficiency (SCID)

A

Low T cells

20
Q

MHC class I presenters

A

All nucleated cells

21
Q

MHC class II presenters

A

Macrophage
Dendritic cell
B cell

22
Q

MHC class I receivers

A

(CD8+)
Cytotoxic T cell
Natural killer cell
Dendritic cell

23
Q

MHC class II receivers

A

(CD4+)
T helper cell (Th1, Th2)
T regulatory cell

BPT Written (20 decks)

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