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Step 1 Review > Immunology > Flashcards

Immunology Flashcards

1
Q

Name the associated HLA allele: Hemochromatosis

A

A3

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2
Q

Name the associated HLA allele: Psoriatic arthritis

A

B27

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3
Q

Name the associated HLA allele: Ankylosing spondylitis

A

B27

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4
Q

Name the associated HLA allele: Inflammatory Bowel Disease

A

B27

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5
Q

Name the associated HLA allele: Reactive arthritis (Reiter Syndrome)

A

B27

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6
Q

Name the associated HLA allele: Celiac Disease

A

DQ2/DQ8

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7
Q

Name the associated HLA allele: Multiple sclerosis

A

DR2

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8
Q

Name the associated HLA allele: SLE

A

DR2, DR3

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9
Q

Name the associated HLA allele: Goodpasture Syndrome

A

DR2

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10
Q

Name the associated HLA allele: DM Type I

A

DR3, DR4

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11
Q

Name the associated HLA allele: Graves Disease

A

DR3

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12
Q

Name the associated HLA allele: Hashimoto Thyroiditis

A

DR3, DR5

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13
Q

Name the associated HLA allele: Rheumatoid arthritis

A

DR4

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14
Q

Name the associated HLA allele: Pernicious anemia

A

DR5

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15
Q

Which stimulus promotes differentiation of an undifferentiated Th cell into a Th1 cell?

A

IL-12

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16
Q

Which stimulus promotes differentiation of an undifferentiated Th cell into a Th2 cell?

A

IL-4

17
Q

Which stimulus promotes differentiation of an undifferentiated Th cell into a Th17 cell?

A

TGF-Beta, IL-6

18
Q

AIRE plays a key role in ______ selection in the thymus.

A

Negative

19
Q

Name the stimulus for Th1 cell activation.

A

IFN-gamma, IL-12

20
Q

Name the stimulus for Th2 cell activation.

A

IL-4

21
Q

What is secreted by Th1 cells?

A

IFN-gamma

22
Q

What is secreted by Th2 cells?

A

IL-4, IL-5, IL-10, IL-13

23
Q

What is secreted by macrophages?

A

IL-12

24
Q

What proteins are released by CTLs when they stimulate apoptosis in infected cells?

A

Perforin, Granzyme

25
Q

What is secreted by Treg cells?

A

IL-10, TGF-Beta

26
Q

What is the costimulatory signal for T-cell activation?

A

B7 (dendritic cell) and CD28 (T-cell)

27
Q

What is the costimulatory signal for B-cell activation?

A

CD40 (B cell) and CD40L (Th cell)

28
Q

What enzyme mediates somatic hypermutation in B cells?

A

Terminal deoxynucleotidyltransferase

29
Q

Which Ig isotype? most abundant in serum

A

IgG

30
Q

Which Ig isotype? Does not fix complement

A

IgA

31
Q

Which Ig isotype? Most produced antibody

A

IgA

32
Q

Which Ig isotype? binds mast cells and basophils

A

IgE

Step 1 Review (15 decks)

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