Biochemistry

Question 1

What is the rate-limiting enzyme for Glycolysis?

Answer 1

Phosphofructokinase-1

Question 2

What is the rate-limiting enzyme for Gluconeogenesis?

Answer 2

Fructose-1,6-Bisphosphatase

Question 3

What is the rate-limiting enzyme for Glycogenesis?

Answer 3

Glycogen Synthase

Question 4

What is the rate-limiting enzyme for Glycogenolysis?

Answer 4

Glycogen Phosphorylase

Question 5

What is the rate-limiting enzyme for The TCA cycle?

Answer 5

Isocitrate Dehydrogenase

Question 6

What is the rate-limiting enzyme for the Hexose Monophosphate Pathway?

Answer 6

Glucose-6-Phosphate Dehydrogenase

Question 7

What is the rate-limiting enzyme for cholesterol synthesis?

Answer 7

HMG-CoA reductase

Question 8

What is the rate-limiting enzyme for Beta-Oxidation?

Answer 8

Carnitine acyltransferase I

Question 9

What is the rate-limiting enzyme for the Urea Cycle?

Answer 9

Carbamoyl phosphate synthetase I

Question 10

What is the rate-limiting enzyme for De novo pyrimidine synthesis?

Answer 10

Carbamoyl phosphate synthetase II

Question 11

What is the rate-limiting enzyme for Fatty acid synthesis?

Answer 11

Acetyl-CoA carboxylase

Question 12

What is the rate-limiting enzyme for De novo purine synthesis?

Answer 12

Glutamine-Phosphoribosylphosphate aminotransferase

Question 13

What is the rate-limiting enzyme for Ketogenesis?

Answer 13

HMG-CoA synthase

Question 14

Hexokinase has ____ affinity and _____ capacity (Vmax) compared to glucokinase.

Answer 14

Increased; decreased

Question 15

Glucokinase has ____ affinity and _____ capacity (Vmax) compared to hexokinase.

Answer 15

Decreased; increased

Question 16

_____ has negative feedback on glucokinase.

Answer 16

Fructose-6-Phosphate

Question 17

_____ has negative feedback on hexokinase

Answer 17

Glucose-6-Phosphate

Question 18

Name the irreversible enzymes in gluconeogenesis and their locations.

Answer 18

Pyruvate carboxylase (mitochondria), Phosophoenolpyruvate kinase (cytosol), Phosphofructokinase-2 (cytosol), Glucose-6-Phosphatase (ER)

Question 19

Which amino acid is the precursor for dopamine?

Answer 19

Phenylalanine

Question 20

Which amino acid is the precursor for Niacin?

Answer 20

Tryptophan

Question 21

Which amino acid is the precursor for Melatonin?

Answer 21

Tryptophan

Question 22

Which amino acid is the precursor for Serotonin?

Answer 22

Tryptophan

Question 23

Which amino acid is the precursor for heme?

Answer 23

Glycine

Question 24

Which amino acid is the precursor for Glutathione?

Answer 24

Glutamate

Question 25

Which amino acid is the precursor for Creatine?

Answer 25

Arginine

Question 26

Which amino acid is the precursor for Nitric oxide?

Answer 26

Arginine

Question 27

Which enzyme is deficient in von Gierke Disease?

Answer 27

Glucose-6-Phosphatase

Question 28

Which enzyme is deficient in Pompe Disease?

Answer 28

Alpha-1,4-glucosidase

Question 29

Which enzyme is deficient in Cori Disease?

Answer 29

Alpha-1,6-glucosidase (Debranching enzyme)

Question 30

Which enzyme is deficient in McArdle Disease?

Answer 30

Glycogen phosphorylase

Question 31

Which enzyme is deficient in Gaucher Disease?

Answer 31

Glucocerebrosidase

Question 32

Which enzyme is deficient in Fabry Disease?

Answer 32

Alpha-galactosidase A

Question 33

Which enzyme is deficient in Niemann-Pick Disease?

Answer 33

Sphingomyelinase

Question 34

Which enzyme is deficient in Tay-Sachs Disease?

Answer 34

Hexosaminidase A

Question 35

Which enzyme is deficient in Krabbe Disease?

Answer 35

Galactocerebrosidase

Question 36

Which enzyme is deficient in Metachromic leukodystrophy?

Answer 36

Arylsulfatase A

Question 37

Which enzyme is deficient in Hurler Syndrome?

Answer 37

alpha-L-iduronidase

Question 38

Which enzyme is deficient in Hunter Syndrome?

Answer 38

Iduronidate sulfatase

Question 39

What accumulates in Fabry Disease?

Answer 39

Ceramide trihexoside

Question 40

What accumulates in Gaucher Disease?

Answer 40

Glucocerebroside

Question 41

What accumulates in Niemann-Pick Disease?

Answer 41

Sphingomyelin

Question 42

What accumulates in Tay-Sachs Disease?

Answer 42

GM2 ganglioside

Question 43

What accumulates in Krabbe Disease?

Answer 43

Galactocerebroside

Question 44

What accumulates in Metachromic Leukodystrophy?

Answer 44

Cerebroside sulfate

Question 45

What accumulates in Hunter/Hurler Syndromes?

Answer 45

Dermatan sulfate, heparan sulfate

Question 46

Lipoprotein B-48 is characteristic of which particle?

Answer 46

Chylomicrons

Question 47

Lipoprotein B-100 is characteristic of which particle?

Answer 47

VLDL/IDL/LDL (binds LDL receptor)