Carcinogenesis

Question 1

Which tumor is implicated? BCR-ABL (2)

Answer 1

CML, ALL

Question 2

Which tumor is implicated? BCL-2 (Anti-apoptotic factor)

Answer 2

Follicular lymphoma

Question 3

Which tumor is implicated? BRAF (Ser/Thr kinase) (2)

Answer 3

Melanoma, Non-Hodgkin lymphoma

Question 4

Which tumor is implicated? c-kit (cytokine receptor)

Answer 4

GIST

Question 5

Which tumor is implicated? c-myc (transcription factor)

Answer 5

Burkitt lymphoma

Question 6

Which tumor is implicated? Her2/neu (Epidermal Growth Factor Receptor/Tyrosine Kinase) (3)

Answer 6

Breast, ovarian, gastric carcinoma

Question 7

Which tumor is implicated? L-myc (Transcription factor)

Answer 7

Small cell carcinoma

Question 8

Which tumor is implicated? N-myc (Transcription factor)

Answer 8

Neuroblastoma

Question 9

Which tumor is implicated? RET (Tyrosine Kinase)

Answer 9

Medullary Thyroid Cancer (MEN2A/MEN2B)

Question 10

Which tumor is implicated? APC

Answer 10

Colorectal cancer

Question 11

Which tumor is implicated? BRCA1/2 (DNA repair)

Answer 11

Breast/Ovarian cancers

Question 12

Which tumor is implicated? DCC

Answer 12

Colon Cancer

Question 13

Which tumor is implicated? DPC4/SMAD4

Answer 13

Pancreatic Cancer

Question 14

Which tumor is implicated? Neurofibromin Mutation

Answer 14

NF1

Question 15

Which tumor is implicated? Merlin protein Mutation

Answer 15

NF2

Question 16

Which tumor is implicated? p16 (CDK inhibitor 2A)

Answer 16

Melanoma

Question 17

Which tumor is implicated? Rb (Inhibits E2F) (2)

Answer 17

Retinoblastoma, osteosarcoma

Question 18

Which tumor is implicated? TSC1 (hamartin), TSC2 (Tuberin)

Answer 18

Tuberous Sclerosis

Question 19

Which tumor is implicated? VHL (inhibits hypoxia inducible factor 1A)

Answer 19

Von Hippel Lindau, Renal cell carcinoma

Question 20

Which tumor is implicated? Cyclin D1

Answer 20

Mantle Cell Lymphoma

Question 21

Which tumor is implicated? CDK4

Answer 21

Melanoma

Question 22

Which tumor is implicated? Elevated alpha-fetoprotein (3)

Answer 22

Hepatocellular carcinoma, Hepatoblastoma, Yolk sac tumor

Question 23

Which tumor is implicated? Elevate Beta-hCG (3)

Answer 23

Hydatidiform mole, choriocarcinoma, testicular cancer

Question 24

Which tumor is implicated? CA 15-3, CA27-29

Answer 24

Breast cancer

Question 25

Which tumor is implicated? CA 19-9

Answer 25

Pancreatic adenocarcinoma

Question 26

Which tumor is implicated? CA125

Answer 26

Ovarian cancer

Question 27

Which tumor is implicated? Calcitonin

Answer 27

Medullary thyroid carcinoma

Question 28

Which tumor is implicated? Chromogranin (2)

Answer 28

Neuroendocrine tumors, small cell carcinoma

Question 29

Which tumor is implicated? S-100 (3)

Answer 29

Melanoma, Schwannoma, Langerhans Cell Histiocytosis

Question 30

Which tumor is implicated? Aflatoxins

Answer 30

Hepatocellular carcinoma

Question 31

Which tumor is implicated? Alkylating Agents

Answer 31

Leukemia/Lymphoma

Question 32

Which tumor is implicated? Aromatic amines (esp. derived from cigarette smoke)

Answer 32

Transitional cell carcinoma

Question 33

Which tumor is implicated? Arsenic (3)

Answer 33

Angiosarcoma (liver), lung cancer, squamous cell carcinoma (skin)

Question 34

Which tumor is implicated? Nitrosamines

Answer 34

Gastric cancer (Intestinal type)

Question 35

Which tumor is implicated? Radon

Answer 35

Lung cancer

Question 36

Vinyl chloride

Answer 36

Angiosarcoma (liver)

Question 37

Name possible paraneoplastic syndromes: Lymphoma

Answer 37

Vitamin D

Question 38

Name possible paraneoplastic syndromes: Small cell lung carcinoma

Answer 38

ACTH, ADH, Lamber-Eaton Myasthenic Syndrome

Question 39

Name possible paraneoplastic syndromes: Renal cell carcinoma

Answer 39

ACTH, PTHrP

Question 40

Name possible paraneoplastic syndromes: Hemangioblastoma, hepatocellular carcinoma, leiomyoma, pheochromocytoma

Answer 40

EPO

Question 41

Name possible paraneoplastic syndromes: Breast cancer

Answer 41

PTHrP