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Immunology Flashcards

1
Q

Alemtuzumab

A

Therapeutic antibody, cancer therapy
Targets CD52
Use in CLL

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2
Q

Bevacizumab

A

Therapeutic antibody, cancer therapy
Targets VEGF
Colorectal cancer, renal cell carcinoma

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3
Q

Cetuximab

A

Therapeutic antibody, cancer therapy
Targets EGFR
Stage IV colorectal cancer, head and neck cancer

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4
Q

Rituximab

A

Therapeutic antibody, cancer therapy
Targets CD20
B-cell non-Hodgkin lymphoma, rheumatoid arthritis (with MTX), ITP

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5
Q

Trastuzumab

A

Therapeutic antibody, cancer therapy
Targets HER2/neu
Breast cancer, gastric cancer

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6
Q

Infliximab

A

Therapeutic antibody, autoimmune disease therapy
Targets TNF-α
IBD, rheumatoid arthritis, ankylosing spondylitis, psoriasis

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7
Q

Adalimumab

A

Therapeutic antibody, autoimmune disease therapy
Targets TNF-α
IBD, rheumatoid arthritis, ankylosing spondylitis, psoriasis

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8
Q

Natalizumab

A

Therapeutic antibody, autoimmune disease therapy
Targets α4-integrin (leukocyte adhesion)
Multiple sclerosis, Crohn disease
Risk of PML in patients with JC virus

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9
Q

Abciximab

A

Therapeutic antibody
Targets glycoprotein IIb/IIIa
Anti-platelet agent for prevention of ischemic complications in patients undergoing percutaneous coronary intervention.

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10
Q

Denosumab

A

Therapeutic antibody
Targets RANKL, mimics osteoprotegrin
Osteoporosis (inhibits osteoclast maturation)

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11
Q

Digoxin immune Fab

A

Therapeutic antibody

Antidote for digoxin toxicity

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12
Q

Omalizumab

A

Therapeutic antibody
Targets IgE. Prevents IgE binding to FcεRI
Allergic asthma.

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13
Q

Palivizumab

A

Therapeutic antibody
Targets RSV F protein
RSV prophylaxis in high-risk infants

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14
Q

Cyclosporine

A

Immunosuppressant
Calcineurin inhibitor. Binds cyclophilin. Blocks T cell activation by preventing IL-2 transcription.
Transplant rejection prophylaxis, psoriasis, rheumatoid arthritis
Nephrotoxicity, hypertension, hyperlipidemia, hyperglycemia, tremor, hirsutism, gingival hyperplasia

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15
Q

Tacrolimus

A

Immunosuppressant
Calcineurin inhibitor. Binds FK506 binding protein (FKBP). Blocks T cell activation by preventing IL-2 transcription
Transplant rejection prophylaxis
Similar to cyclosporine; nephrotoxicity, increased risk of diabetes and neurotoxicity. No gingival hyperplasia or hirsutism

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16
Q

Sirolimus (Rapamycin)

A

Immunosuppressant
mTOR inhibitor. Binds FKBP. Blocks T cell activation and B cell differentiation by preventing IL-2 signal transduction
Kidney transplant rejection prophylaxis, drug-eluting stents. Synergistic with cyclosporine.
Anemia, thrombocytopenia, leukopenia, insulin resistance, hyperlipidemia, non-nephrotoxic.

17
Q

Basiliximab

A

Immunosuppressant
Monoclonal antibody to IL-2R
Kidney transplant rejection prophylaxis
Edema, hypertension, tremor

18
Q

Azathioprine

A

Immunosuppressant
Antimetabolite precursor of 6-mercaptopurine. Inhibits lymphocyte proliferation by blocking nucleotide synthesis
Transplant rejection prophylaxis, rheumatoid arthritis, Crohn disease, glomerulonephritis, other autoimmune conditions
Leukopenia, anemia, thrombocytopenia, toxicity increased by allopurinol

19
Q

Glucocorticoids

A

Immunosuppressant
Inhibits NF-κB. Suppresses both B and T cell function by decreasing transcription of many cytokines.
Transplant rejection prophylaxis (immune suppression), many autoimmune disorders, inflammation
Hyperglycemia, osteoporosis, central obesity, muscle breakdown, psychosis, acne, hypertension, cataracts, peptic ulcers (iatrogenic Cushing syndrome).

20
Q

Epoetin alfa

A

Recombinant cytokine
EPO
Anemias, especially in renal failure

21
Q

Thrombopoietin

A

Recombinant cytokine

Thrombocytopenia

22
Q

Oprelvekin

A

Recombinant cytokine
Interleukin-11
Thrombocytopenia

23
Q

Filgrastim

A

Recombinant cytokine
Granulocyte colony-stimulating factor
Recovery of bone marrow

24
Q

Sargramostim

A

Recombinant cytokine
Granulocyte-macrophage colony-stimulating factor
Recovery of bone marrow

25
Q

Aldesleukin

A

Recombinant cytokine
Interleukin-2
Renal cell carcinoma, metastatic melanoma

26
Q

IFN-α

A

Recombinant cytokine
Chronic hepatitis B and C, Kaposi sarcoma, hairy cell leukemia, condyloma acuminatum, renal cell carcinoma, malignant melanoma

27
Q

IFN-β

A

Recombinant cytokine

Multiple sclerosis

28
Q

IFN-γ

A

Recombinant cytokine

Chronic granulomatous disease

Pharmacology (19 decks)

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