Immunology Flashcards
What are dendritic cells?
Specialised cells that carry antigens to T lymphocytes in lymph tissue
Is the brain an immuno-priviledged organ? How?
BBB, and CNS microenvironment
Lack of communication with the CNS and Lymphatic organs.
Where are Macrophages and dendritic cells in the lymph node?
Cortex and paracortex.
Where are T cells located in the lymph node?
The Paracortex
Where are B cells located in the lymph node?
Cortex
What are the two types of B cell response?
T-cell dependent and T-cell independent
Three types of lymphocytes?
B cell
T helper (TH)
T killer (Tc)
How many loci does the MHC molecule have?
6
What does the T-cell receptor do?
Binds to the MHC molecules and recognises antigens presented by them
What is the difference between the MHC I and MHC II pathways?
MHC I is endogenous (gets peptide from within the cell)
MHC II is exogenous (uses endocytosis to get a foreign antigen)
What MHC is presented on ALL cells?
MHC I
What does MHC class I do?
It presents antigens from within the cell, these are normally self antigens, but if the cell is virally infected it will be a foreign antigen
What does MHC class II do?
Presents a foreign peptide to activate lymphocytes
What cells present MHC II?
APC cells, Dendritic cells, macrophages, B cells
Autoimmune disease classifications, their meanings?
Type I: IgE mediated
Type II: IgG mediated
Type III: immune complex mediated
Type IV: Cell mediated
