Immunology

Question 1

The origin of constant region of monoclonal antibody?

Answer 1

The constant region of the antibody is human in origin. They are made by identical immune cells that are all clones of a unique parent cell, hence the name ‘monoclonal’. The constant region of these antibodies, also known as the Fc region, is typically human in origin.

Question 2

infliximab (anti-TNF): used in??

Answer 2

RA and Crohns

Question 3

rituximab (anti-CD20): used in??

Answer 3

RA and Non Hodgkins lymphoma

Question 4

cetuximab (epidermal growth factor receptor antagonist): used in??

Answer 4

Metastatic CRCA
and
H&N CA

Question 5

trastuzumab (HER2/neu receptor antagonist): used in??

Answer 5

Mets CA Breast

Question 6

alemtuzumab (anti-CD52): used in??

Answer 6

CLL

Question 7

abciximab (glycoprotein IIb/IIIa receptor antagonist): used in??

Answer 7

Prevention of ischemic events esp those undergoing PCIs

Question 8

OKT3 (anti-CD3): used in??

Answer 8

Prevention of Organ Rejection

Question 9

In severe infection, which proteins increase??

Answer 9

Positive acute phase reactant proteins

{CRP
procalcitonin
ferritin
fibrinogen
alpha-1 antitrypsin
caeruloplasmin
serum amyloid A
serum amyloid P component
haptoglobin
complement}

Question 10

In infection which proteins are negative acute phase reactants??

Answer 10

During the acute phase, the liver decreases the production of other proteins (negative acute phase proteins). Include:
albumin
transthyretin (formerly known as prealbumin)
transferrin
retinol binding protein
cortisol binding protein