Biochemistry

Question 1

What is the second wind phenomenon in McArdle disease?

Answer 1

-Occurs when patients experience an improvement in exercise tolerance after a brief rest or reduction in intensity
-Due to the body’s switch from glycogen-dependent energy metabolism to increased reliance on circulating glucose and fatty acids
-His adaptation allows for better energy utilisation during prolonged activity despite the underlying myophosphorylase deficiency.

Question 2

McArdle disease??

Answer 2

Autosomal recessive type V glycogen storage disease
{myophosphorylase deficiency}
-Causes decreased muscle glycogenolysis

Question 3

How the pt with McArdle disease presents to you?

Answer 3

-Muscle pain and stiffness following exercise
-Muscle cramps
-Second wind phenomenon
-rhabdomyolysis & myoglobinuria
-Low lactate levels during exercise