Immunology Flashcards
agents that have capacity for both positive and negative actions
immunomodulator
stimulate the immune response
immunostimulant
most effective when used in combination with antigen administration
immunoadjuvants
substances which have the ability to attenuate the immune response
immunosuppressants
CSFs, interleukins, interferons, MDP, potent immunopharmacology
biological response modifiers
boosts a failing immune system
immunopotentiator
mediators of the immune response with pro-inflammatory, regulator, CSF/hematopoietic growth factors, or interferon activity
cytokines
make up 50-60% of WBC, first to respond
neutrophils
two leukocytes that act as an antigen presenting cell
macrophages, monocytes
first line of defense that is nonspecific, has no memory, and it an immediate defense
innate immunity
delayed but amplified immune reaction with specific memory
adaptive immunity
lymphocytes make up what % if WBC
25-35%
cells responsible for humoral immunity
B-lymphocytes
B-lymphocyte role
Ab production
what can Ab do?
activate complement
facilitate opsonization
neutralize viruses
cytotoxicity of cells
direct antimicrobial action
reduce damage of inflammation
cells responsible for cell mediated immunity
T-lymphocytes
CD8+ killer, CD4+ helper
active naturally acquired
Ag enters body, body induces Ab
ex) infection
passive naturally acquired
IgG Ab pass from mother to fetus
active artificially acquired
Ag introduced in vaccines, body produces Ab
passive artificially acquired
pre-formed Ab in immune serum introduced by injection (immunoglobulins)
genetic defects resulting in impaired function of the immune system
primary immunodeficiency
non-genetic and acquired over lifetime (ex. transplant patient)
secondary immunodeficiency
diseases caused by the bod’s immune system initiating an immune reaction against self antigens or auto antigens
autoimmune disease
human GM-CSF that exhibits a dose dependent increase in production of neutrophils and monocytes and may improve their function
Sargramostim (Leukine)
Leukine uses
myelosuppressive chemotherapy, bone marrow transplant, myelodysplastic syndromes, HIV, chemotherapy induced neutropenia
AEs of Leukine
fever, diarrhea, NV, malaise, weakness, chills, headache, rash
exogenous G-CSF that increases nadir neutrophil counts
FIlgrastim (Neupogen), Pegfilgrastim (Neulasta)
uses for neupogen/neulasta
bone marrow transplant, myelodysplastic syndromes, HIV, chemotherapy induced neutropenia
AEs of neupogen/neulasta
bone pain, NV, marked leukocytosis, increased uric acid, hypersensitivity reactions
exogenous CSF that acts like endogenous EPO and stimulates erythroid progenitors in bone marrow to differentiate and mature into RBCs
Epoetin-Alfa (Procrit), Darbepoetin Alfa (Aranesp)
AEs of epo-A
HTN, fever, NV, headache, rash, itching, joint aches, cough
recombinant human interferon that induces the innate antiviral immune response and inhibits viral replication of virus infection cells, suppresses cell cycle progression, and induces apoptosis
peginterferon alfa-2a (Pegasys), Peginterferon Alfa-2b (Pegintron)
uses for pegasys/pegintron
hepatitis C
AEs of pegasys/pegintron
bone pain, myalgia, HA, fatigue, fever, neutropenia
IVIG containing pooled IgG Ab used for primary immunodeficiency or idiopathic thrombocytopenia purpura
Gammagard S/D, Gamunex, Ocagam
AEs of gammagard
myalgia, arthralgia, NV
what is human anti-mouse antibodies (HAMA) reaction?
hypersensitivity to the source of Ab in a MoAb
agents that modify activity of TNF-a to reduce inflammation
etanercept (enbrel), infliximab (remicade), adalimumab