Hyperlipidemia Flashcards
statin CI
active liver disease
unexplained elevated AST or ALT x3 ULN
Pregnant or nursing women
major DDIs
statins metabolized by CYP3A4
lovastatin > simvastatin > atorvastatin
statin AEs
diarrhea, arthralgia, nasopharyngitis, myalgia
hydrophilic statins
pravastatin and rosuvastatin
long 1/2 life statins
atorvastatin > rosuvastatin > pitavastatin
atorvastatin high intensity dose
40-80
rosuvastatin high intensity dose
20-40
atorvastatin moderate intensity dose
10-20
rosuvastatin moderate intensity dose
5-10
simvastatin moderate intensity dose
20-40
pravastatin moderate intensity dose
40-80
lovastatin moderate intensity dose
40
fluvastatin moderate intensity dose
80
pitavastatin moderate intensity dose
2-4
simvastatin low intensity dose
10