Immunohistochemistry And tumor Markers

Question 1

It is the identification of specific or selective tissue or cellular antigens found on tissues

Answer 1

Immunohistochemistry

Question 2

Controls in immunohistochemistry

Answer 2

Positive control
Negatuve control
Internal tissue control

Question 3

Also known as built in control

Answer 3

Internal tissue control

Question 4

A control that is a section of proven and known to have the antigen in question

Answer 4

Positive control

Question 5

A control that omits the primary antibody from the staining schedule

Answer 5

Negative control

Question 6

Tyoe of label that uses substrates with chromogen such as Diaminobenzidine(dark brown)

Answer 6

Enzyme labels

Question 7

A label using fluorescein isothiocyanate

Answer 7

Fluorochrome labels

Question 8

EMA stands for

Answer 8

Epithelial membrane antigen

Question 9

A tumor marker for epithelial cells

Answer 9

Keratin

Question 10

Tumor marker that distinguishes lung adenocarcinoma from mesothelioma

Answer 10

TTF-1 or Thyroid Transcription Factor - 1

Question 11

Most specific tumor marker only found in the prostate

Answer 11

PSA or Prostate Specific Antigen

Question 12

Tumor marker for determining the site of tumor

Answer 12

EMA

Question 13

Marker for colon cancer

Answer 13

CEA or Carcinoemrbyonic Antigen

Question 14

Breast cancer marker

Answer 14

ER/PR

Question 15

Tumor marker highly specific for myogenic tumors

Answer 15

Desmin

Question 16

Tumor marker that is normally expressed by CNS glial cells especially astrocytes

Answer 16

GFAP (Glial Fibrillary Acidic Protein)

Question 17

A germ cell tumor marker that detects early pregnancy

Answer 17

HCG (Human Chorionic Gonadotropin)

Question 18

Tumor marker synthesized by liver

Answer 18

AFP (Alpha-Fetoprotein)

Question 19

Tumir marker detected in late pregnancy

Answer 19

Placental-like alkaline antigen (PLAP)

Question 20

Described as tumors if skeletal muscle origin

Answer 20

Myogenic tumors

Question 21

LCA (Leukocyte Common Antigen) is also known as

Answer 21

CD45