IMMUNODEFICIENY DISORDERS Flashcards
Primary immunodeficiencies
B cell disorders, t cell disorders, combined b and t cells, phagocyte disorders, complement disorders
Recurrent infections with pyogenic bacteria indicate a immunodeficiency in
B cells
B cell disorders
X linked/ Bruton’s agammaglobinemia,selective IgA deficiency
T cell disorders
DiGeorge Syndrome, chronic mucocutaneous candidiasis
Combined B and T cell disorders
Severe combined immunodeficiency, wiskott aldrich syndrome, ataxia telangiectasia
Phagocyte disorders
Chronic granulomatous disease, chediak higashi syndrome, leukocyte adhesion deficiency
Complement disorders
Early- C2, C3; terminal- specific deficiency
Very low levels all immunoglobulins; virtual absence of B cells due to tyrosine kinase mutation
Bruton’s aggamoglobinemia
Mgmt for bruton’s
Pooled gamma globulin
Selective IgA deficiency
Due to failure of isotype switching and result to recurrent bacterial sinus and lung infectiob
Defect in B cell maturation to plasma cells
Common variable immunodeficiency
Most common form of severe antibody deficiency affecting both children and adults
Common variable immunodeficiency
Specific T cell deficiency for candida albicans
Chronic mucocutaneous candidiasis
Defect jn IL2 receptors in T cells, ADA deficiency
SCID
Inability to mount IgM response
Wiskott Aldrich syndrome
