IMMUNO SERO Flashcards

1
Q

is the study of a host’s reactions when foreign substances are introduced into the body

A

IMMUNOLOGY

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2
Q

function of the immune system is to recognize self from nonself and to defend the body against nonselfsystems
responsible for the recognition and disposal of foreign (nonself ) material

A

IMMUNOLOGY

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3
Q

One of the deadliest diseases known to humans

A

SMALLPOX

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3
Q

a form of variolation used (in China)

A

insufflation

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3
Q

study of blood serum (the clear fluid that separates when blood clots)

A

SEROLOGY

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4
Q

earliest practice of variolation

A

Lady Mary
Wortley Montagu

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5
Q

generally considered to be the Father of
Immunology for his use of attenuated vaccine

A

Louis Pasteur

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6
Q

a phenomenon known as phagocytosis and a fundamental
part of the immune response

A

Elie Metchnnikoff

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7
Q

Components of the natural immune system: Cellular

A

-Mast cells
-Neutrophils
-Macrophages

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8
Q

Components of the natural immune system: Humoral

A

-Complement
-Lysozyme
-Interferon

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8
Q

Components of the Adaptive Immune System: Cellular

A

-T lymphocytes
-B lymphocytes
-Plasma cells

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9
Q

Components of the Adaptive Immune System: Humoral

A

-Antibodies
-Cytokines

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10
Q

are molecules associated with groups of pathogens that are recognized by cells of the innate immune system.

A

PAMPs (pathogen-associated molecular patterns )

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11
Q

These inflammatory components liberated from damaged cells include nucleic acids, intracellular proteins, extracellular
matrix components, oxidized lipids, crystals such as uric acids, silica, β-amyloid, and cholesterol

A

DAMPS (damage associated molecular patterns)

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12
Q

The receptors of the innate immune system that recognize these PAMPs are called

A

pattern recognition receptors (PRRs)

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13
Q

Three groups of PRRs exist

A
  • Secreted PRRs
  • Phagocytosis receptors
  • Toll-like receptors (TLRs)
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14
Q

type of adaptive immunity

A
  • antibodies from mother to child
    *immunoglobulins for rabies infection
  • attenuated vaccines
  • Toxoids
  • Convalescence plasma treatment
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15
Q

a substance that stimulates antibody
formation

A

antigen

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16
Q

ability to bind to an antibody or a
T lymphocyte antigen receptor but may not be able to evoke
an immune response initially.

A

antigen

17
Q

all immunogens are antigens but not all
antigens are immunogens

A

true

18
Q

PHYSICAL CHARACTERISTICS

A
  • Foreignness
  • Degradability
  • Molecular Weight
  • Structural Stability
  • Complexity
19
Q

CHEMICAL NATURE

A

large organic molecules that are proteins or large polysaccharides and,
rarely, if ever, lipids.

20
Q

excellent antigens because of their high molecularweight and
structural complexity

A

protein

21
Q

considered inferior antigens because of their relative simplicity and lack of structural stability.

A

lipids

22
Q

poor antigens because of relative simplicity, molecular
mflexibility, and rapid degradation

A

nucleic acids

23
Q

combination of biochemical classes

A

Glycolipids and glycoproteins (HLA)

24
Q

part of an antigen, reacts specifically with an antibody or T lymphocyte receptor.

A

epitope

25
Q

antigenic but are not immunogenic

A

HAPTENS

26
Q

immunogenic

A

hapten+ carrier protein

27
Q

Cellular antigens of importance include histocompatibility antigens, autoantigens, and blood group antigens

A

ENDOGENOUS ANTIGEN

28
Q

intracellular pathogens

A

ENDOGENOUS ANTIGEN

29
Q

APC - T HELPER CELL( CD4) - MHC II

A

EXOGENOUS ANTIGEN (OUTSIDE )

30
Q

Cellular antigens of importance include histocompatibility antigens, autoantigens, and
blood group antigens

A

ENDOGENOUS ANTIGEN

31
Q

Ag found on the membranes of almost all the cells of human body

A

Major
Histocompatability Antigens

32
Q

targets of T lymphocytes
that regulate the immune response

A

Both class I and class II antigens function

33
Q

Also known as “immunoglobulin”

A

ANTIBODY

34
Q

glycoproteins found in the
serum portion of the blood, constitute approx. 20% of plasma
proteins.

A

antibody

35
Q

Serum electrophoresis

A

proteins are separated out on the basis of size and charge

36
Q

All immunoglobulin molecules are made up of a basic four chain tetrapeptide
unit that consist of

A
  • 2 large chain called heavy or H chain
  • 2 smaller chains called light or L chains
37
Q

proteolytic enzymes used to
cleaved Antibody structres

A

-Papain
-pepsin

38
Q

Present in blood, plasma, and tissue
fluids

A

Immunoglobulin G

39
Q

Normal human adult serum values
of IgG

A

800 to 1800 mg/dL (90 to
210 IU/mL)

40
Q

the longest of all of the Ig isotypes

A

IgG

41
Q

The ability of a particular antibody to combine with a particular antigen

A

Specificity

42
Q

occurs between bacteria that possess
the same cell wall polysaccharides as mammalian erythrocytes

A

Cross-reactivity