immuno buzzwords Flashcards
rolling, adhesion, arrest, diapedesis
leukocyte adhesion cascade: process of leukocytes in vasculature adhering to tissue, being activated, and extravasating into tissues to act as phagocytes
C1q, C1r, C1s, C2, C4
classical complement pathway: C1q binds pathogen
activates cleavage of C1r, C1s, C2, C4
C3 convertase
point in which all 3 complement pathways converge
spontaneous hydrolysis of C3 to C3-H2O, binding B and cleavage by D to C3bBb
alternative complement pathway
MASP 1, 2 cleaving C2, C4
mb-lectin complement pathway
opsonizing C3b
complement opsonization
C3a, C5a
complement anaphylatoxins that cause phagocyte migration
C5-C9, membrane attack complex
membrane attack complex of complement, causing lysis
first antibody produced, primary response, fixes complement
IgM
most abundant antibody, can fix complement, switch from IgM, crosses placenta
IgG
antibody on mucosal surfaces, in secretions, doesn’t fix complement
IgA
antibody in type I HS, parasitic infections, eosinophils, mast cells
IgE
IL-12, IFN-y, activate macrophages, intracellular pathogens
TH1
IL-17, IL-21, enhance neutrophil response, extracellular pathogens
TH17
IL-4, IL-5, activate response against parasites
TH2
IL-6, activate B cells, maturation of antibody response
Tfh
IL-10, suppress effector T cells
Treg
allergy, IgE, wheal and flare, eosinophils, TH2
type 1 HS
antigen-antibody complexes, hypersensitivity
type 2 HS
