Immuno Flashcards
Low B-cell count + Low IgA, IgM, IgG
Bruton’s agammaglobulinaemia
Cleft lip / palate, hypocalcaemia, low T-cell count (+ cardiac abnormalities / thymic aplasia)
Di George’s syndrome (CATCH symptoms)
22q11 deletion
Reduced IgM and raised IgA + IgE.
Clinically: Eczema / nosebleeds / bruising
Wiskott-Aldrich syndrome
Mutation of MHC III + mild pneumonia
Common variable immunodeficiency
Jaundice + hepatomegaly + sclerosing cholangitis with a defect in either MHC I (CD8+ T cells) or MCH II (CD4+ T Cells)
Bare lymphocyte syndrome
Anti-cyclic citrullinated protein
Rheumatoid arthritis
Anti-smooth muscle antibodies
autoimmune hepatitis / PSC
Anti-Jo1
Dermatomyositis
Anti-centromere
Limited systemic scleroderma (CREST syndrome)
Anti-topoisomerase
Diffuse systemic scleroderma (more aggressive than limited systemic scleroderma (CREST)).
Pulmonary Fibrosis is defining feature
Anti-Ro + Anti-La
Present in 50% of Sjogren’s patients
Anti-glutamic acid decarboxylase
Type 1 Diabetes Mellitus
‘Saddle-shaped’ nose
Wegner’s granulamatosis (Granulomatosis with polyangiitis (GPA))
Anti-endomysial
Ceoliac
CSF demonstrates oligoclonal bands of IgG on electrophoresis
Multiple Sclerosis (MS)
Western blot test
HIV
Kveim Test
Sarcoidosis
Direct antiglobulin test (DAT) (aka Direct Coombs test)
Autoimmune haemolytic anaemia (AIHA)
Skin prick test
Hypersensitivity reactions e.g. peanuts
Recurrent mild pneumonias / diarrhoea but otherwise fine
Selective IgA deficiency
CTL4- immunoglobulin fusion protein
Abatacept (used in long-standing rheumatoid arthritis)
Anti-TNF α
Infliximab
Drug - prevents guanine synthesis and induces immunosuppression
Mycophenolate mofetil
HLA DQ2
Coeliac
HLA B27
Ankylosing spondylitis