Immunity to Microorganisms Flashcards
What makes an organism a pathogen?
Its ability to successfully evade the immune system
In most cases what kills microorganisms within the body?
Phagocytic cells
What do Cytotoxic T cells kill?
Infected host cells
What is the function of specific immunity?
To enhance the uptake of microorgaisms by phagocytic cells or to enhance the activity of phagocytic cells
What are the barriers that comprise the innate immune system?
1- Skin 2- pH barriers 3- Flushing 4- Lysozyme 5- Phagocytes 6- Compliment
What does lysozyme destroy?
the cross links in bacterial cell walls
What are virulence factors?
mechanisms that bacteria have that give them the ability to evade host defenses
What is the primary adaptive immune response of the body?
antibody
What is the role of antibody?
1- prevent the attachment to epithelium 2- trigger compliment 3- bind to antiphagocytic M proteins or capsules 4- Neutralize toxins 5- neutralizing spreading factors 6- opsonize bacteria
What is a characteristic of facultative intracellular parasites?
ability to survive within a phagosome (with help of T3SS)
What kills bacteria that can survive in normal macrophages?
activated macrophages
What is the function of activated macrophages?
non-specific kil;ing
Is there long term immunity from activated macrophages?
no there is no because it is not T cell mediates so no memory cells can be made
Where does immunological memory exist, cells or serum?
Cells
Which cells in specific transfer specific immunity?
CD4+
What mediates specific kiiling? What mediates non-specific killing?
specific killing= T cells
non-specific killing= activated macrophages
The mechanism of antigen presentation is important for what?
the type of immune response that develops
What cells are important for immunity to parasites?
CD8+
Which cytokines does Tubercoid leprosy favor?
Th1
Which cytokines does Leprosy leprosy favor?
Th2
What does Th1 stimulate?
cell mediated immunity
What does Th2 stimulate?
antibody immunity
