Immune system Flashcards

1
Q

What does the Immune system does

A

works to defend body against

internal and external threats

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2
Q

What 2 systems work together in immunity

A

Immune and lymphatic systems

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3
Q

What does the immune system consists of

A

1) Contains no organs or tissues
2) Instead consists of cells and proteins in blood and tissues of other systems
3) including lymphatic system

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4
Q

What formed elements does the immune system has

A

1) leukocytes, or white blood cells (WBCs)

2) immune proteins located in plasma

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5
Q

What is immunity?

A

is the ability to ward off damage or disease through our defenses

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6
Q

What is susceptibility

A

lack of resistance

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7
Q

What are the two general types of immunity

A

Innate (nonspecific)

Adaptive (specific)

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8
Q

What is innate (nonspecific) immunity

A

1) nonspecific defense mechanisms that come into play immediately or
within hours of an antigen’s appearance in the body.
2) Physical barriers such as skin, chemicals in the blood, and immune system cells that attack foreign cells in the body

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9
Q

What is adaptive (specific) immunity

A

1) antigen-specific immune response
2) More complex than nonspecific
3) The antigen first must be processed and recognized. Once an antigen has been recognized, the adaptive immune system creates an army of immune cells specifically designed to attack that antigen.
4) Adaptive immunity also includes a “memory” that makes future responses against a specific antigen more efficient.

(long memory, when you do not have to put more than 1 vaccine)

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10
Q

What is the Lymphatic system

A

group of organs and tissues that not only works with immune system but also participates in number of functions such as fluid
homeostasis

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11
Q

What are the two main components of the lymphatic system

A

1) lymphatic vessels

2) lymphatic tissue and organs

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12
Q

What are the Lymphatic vessels

A

system of blind-ended tubes

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13
Q

What are some components of the Lymphatic tissue and organs

A

includes clusters of lymphoid follicles such as

1) Tonsils
2) Lymph nodes
3) Spleen
4) Thymus

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14
Q

What are the major functions of the lymphatic system

A

1) Regulation of interstitial fluid volume
- interstitial fluid and lymph are similar in composition
- returns fluid and any leaked plasma proteins to the blood
2) Absorption of dietary fats
3) Immune functions
- lymphoid organs filter pathogens from lymph and blood antigens provoke responses by B cells, plasma cells (which produce antibodies),
memory B cells, and several types of T cells including helper T cells, cytotoxic T cells, regulatory T cells and memory T cells

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15
Q

Where is the lymph collected

A

In vessels called lymph-collecting vessels

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16
Q

lymph-collecting vessels merge to form what

A

lymph trucks

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17
Q

How many lymph trunks drain lymph from specific body

regions

A
9
1) lumbar trunks
2) Intestinal trunk 
3) Jugular trunk 
4) Bronchomediastinal trunks 
5) Subclavian trunks 
6)
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18
Q

Where does the lumbar trunks receive lymph from

A

receive lymph from lower limbs and pelvic area

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19
Q

Where does the Intestinal trunk receives lymph from

A

receives fat-containing lymph from small lymphatic vessels—in small intestine

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20
Q

Where does Broncho mediastinal trunks receive lymph from

A

Receive lymph from thoracic cavity

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21
Q

Where does the Subclavian trunks receive lymph from

A

receive lymph from upper limbs

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22
Q

Where does the Jugular trunks receive lymph from

A

receive lymph from head and neck

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23
Q

Where does the Intestinal trunk and lumbar trunks

all drain into

A

a large, swollen vessel called cisterna chyli

24
Q

Cisterna chyli and trunks from left side of

body drain into which duct?

A

thoracic duct

25
Where does the Thoracic duct, largest lymphatic duct, drains | into
into the junction of the left internal jugular and left | subclavian veins
26
Who makes up low-pressure circuit to drive lymph through vessels
Lymphatic vessels
27
What prevents lymph from flowing backward
Valves
28
Lymph flow through vessels is driven in part by
contractions of smooth muscle found in walls of lymph- collecting vessels
29
Why do the Cells of lymphatic capillary walls are not | tightly joined but able to flap open and close
To allow macrophages and other immune cells to | enter lymph
30
What are the Lymph nodes
clusters of lymphoid organs along pathway of lymphatic vessels
31
What do the Lymph nodes limit
spread of pathogens through the body by acting as filters | trap pathogens and prevent them from traveling elsewhere
32
What has an easier time entering lymphatic | capillaries than blood capillaries
Pathogens such as bacteria and cancer cells in interstitial fluid
33
What is the predominant tissue type of the lymphatic system
lymphoid tissue | loose connective reticular tissue
34
Lymphoid organs house
Leukocytes
35
What are the Macrophages
mature monoctes
36
What are B and T lymphocytes
agranulocytes with diverse immune functions
37
What are Dendritic cells
immune cells with spiny processes resembling dendrites of neurons derived from bone marrow while others originate from connective tissue
38
What are Reticular cells
particularly abundant in organs such as spleen and lymph nodes produce reticular fibers composed of specialized, thin collagen protein
39
What is the Mucosa-associated lymphatic tissue (MALT)
loosely organized clusters of lymphoid tissue
40
What does MALT protect
1) protects mucous membranes, which are exposed to large number of pathogens 2) oral and nasal cavities scattered throughout gastrointestinal tract, respiratory passages, and, to limited extent, genitourinary tract
41
Much of MALT in body consists of
loosely organized clusters of B and T cells that lack connective tissue capsule
42
Peyer’s patches defends against of
any bacteria that have escaped from large intestine
43
Appendix defends against of
- defends body from bacteria in large | intestine
44
What does Epithelium lining tonsils form
tonsillar crypts that trap bacteria and debris 1) Pharyngeal tonsils (2) 2) Palatine tonsils (2) 3) Lingual tonsil (1)
45
what are Lymph nodes
small, vaguely bean-shaped clusters of lymphatic tissue located along lymphatic vessels throughout body
46
Specific clusters of lymph nodes include
1) axillary lymph nodes 2) cervical lymph nodes 3) inguinal lymph nodes 4) mesenteric lymph nodes
47
What does Lymph nodes have
1) external connective tissue capsule 2) surrounds network of reticular fibers filled with 3) macrophages, lymphocytes, and dendritic cells
48
What are the Interior of node divided into... (2)
outer cortex and inner medulla
49
What traps approximately 90% of | pathogens in lymph
Lymph nodes and it prevents pathogens from being delivered to blood, where they could easily spread to other tissues and organs
50
Lymph that has been “cleaned” of pathogens | drains out... where?
through efferent lymphatic vessels on other side of node | at hilum
51
What is the Spleen and where is located
largest lymphoid organ in body located on lateral side of left upper quadrant of abdominopelvic cavity
52
the internal structure of the spleen consists of
network of reticular fibers
53
Two distinct histological regions in reticular network
1) Red pulp—contains macrophages that destroy old erythrocytes 2) White pulp—filters pathogens from blood and contains leukocytes and dendritic cells
54
Adult thymus
Consists of subunits called thymic lobules (thymic corpuscles Each lobule contains two regions: outer cortex and inner medulla -Cortex contains densely packed T cells -Medulla contains fewer T cells - Site of destruction of certain populations of T cells that could react to body’s own cells
55
Edema
(swelling)—accumulation of excess | interstitial fluid
56
Lymphadenopathy
Occurs when the lymph | nodes swell due to infections.
57
Filariasis
An infection of the lymphatic channels by a | worm or parasite.